Supplier: Bioss

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZDHHC1 (zinc finger, DHHC-type containing 1), also known as ZNF377 (zinc finger protein 377) or C16orf1, is a 485 amino acid multi-pass membrane protein that contains one DHHC-type zinc finger. Expressed in fetal heart, lung and kidney and also present in adult lung and pancreas, ZDHHC1 functions as a palmitoyltransferase that catalyzes the conversion of palmitoyl-CoA and protein-cysteine to S-palmitoyl protein and CoA. Like ZDHHC1, ZDHHC5, ZDHHC6, ZDHHC7 and ZDHHC18 each contain one DHHC-type zinc finger through which they convey palmitoyltransferase activity against a broad range of substrates, including H-Ras, SNAP 25 and GABAA R proteins.

Supplier: Bioss

Interleukin 11 is a pleiotropic cytokine produced by mesenchymal-derived adherent cells. IL11 shares many functions of IL6 and LIF, including potentiation of megakaryocyte activity, enhancement of human myeloma cell proliferation, and enhancement of hepatic acute phase protein production.Interleukin 11 directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells, and induces megakaryocyte maturation resulting in increased platelet production. Clinically it is used to prevent severe thrombocytopenia and the reduction of the need for platelet transfusion following myelosuppressive chemotherapy.

Supplier: Bioss

Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.

Supplier: Thermo Fisher Scientific

Appearance: White to off-white Powder

Supplier: US Biological

Anti-MAP Kinase 10 Rabbit Monoclonal Antibody [clone: 10F662]

Supplier: Biotium

This antibody recognizes a protein of 25-26 kDa, identified as the bcl-2 α oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2 α oncoprotein inhibits programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 α protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.

Supplier: Biotium

Recognizes a glycoprotein of ~200 kDa, identified as carbonic anhydrase IX (CAIX/gp200). Its epitope resides in the carbohydrate domain of gp200. It shows no significant cross-reactivity with other carbohydrate determinants, such as the Lewis blood group antigens, epithelial membrane antigen, HMFG, and AB blood group antigens. In normal kidney, gp200 is localized along the brush border of the pars convoluta and pars recta segments of the proximal tubule, as well as focally along the luminal surface of Bowman's capsule adjoining the outgoing proximal tubule. Reportedly, gp200 is expressed by 93% of primary and 84% of metastatic renal cell carcinomas. This MAb may be useful in the investigations of carcinomas of proximal nephrogenic differentiation especially those showing tubular differentiation.

Supplier: Biotium

This MAb reacts with an N-terminal epitope (aa 16-25) of both wild type and mutated p53. Mutation and/or allelic loss of p53 is one of the causes of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. In most transformed and tumor cells the concentration of p53 is increased 51000 fold over the minute concentrations (1000 molecules cell) in normal cells, principally due to the increased half-life (4 h) compared to that of the wild-type (20 min). p53 Localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution. Mutations arise with an average frequency of 70% but incidence varies from zero in carcinoid lung tumors to 97% in primary melanomas. High concentrations of p53 protein are transiently expressed in human epidermis and superficial dermal fibroblasts following mild ultraviolet irradiation. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia.

Supplier: Bioss

Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyses the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.

Supplier: US Biological

Anti-pro-Guanylin Mouse Monoclonal Antibody [clone: MAK-L-G-11]

Supplier: Abcam

Rabbit monoclonal [EPR18170-142] to GRO gamma - BSA and azide free.

Supplier: Apollo Scientific

(R)-3,3'-Bis[3,5-dimethylphenyl]-1,1'-binapthyl-2,2'-diyl hydrogenphosphate

Supplier: Apollo Scientific

Ethyl-7-amino-2-methyl-3-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-6-carboxylate

Supplier: Abcam

Mouse monoclonal [KRT17/778] to Cytokeratin 17 - BSA and Azide free.

Supplier: Abcam

Mouse monoclonal [KRT8.18/1346] to Cytokeratin 8+18.

Supplier: Abcam

Rabbit monoclonal [73-10] to PD-L1 - BSA and Azide free.

Supplier: Apollo Scientific

1,3-dimethyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid 95%

Supplier: Apollo Scientific

7-Amino-2-methyl-3-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-6-carboxylic acid

Supplier: Apollo Scientific

Methyl-5-cyano-1,6-dihydro-1-(4-fluorophenyl)-4-methyl-6-pyridazinone-3-carboxylate 97%

Supplier: Apollo Scientific

3-Benzylpiperidine-1,3-dicarboxylic acid-1-tert-butyl ester-3-ethyl ester

Supplier: Abcam

Rabbit monoclonal [EPR22248-141] to VEGF Receptor 1 - BSA and Azide free (Detector).

Supplier: Abcam

Rabbit monoclonal [EPR26408-18] to IGF2BP1/IMP1 - BSA and Azide free.

Supplier: Abcam

Rabbit monoclonal [EPR21764-154] to Tissue kallikrein - BSA and Azide free (Detector).

Supplier: Abcam

Rabbit monoclonal [UDD3 30(12)] to LRRK2 - BSA and Azide free.

Supplier: Abcam

Rabbit monoclonal [EPR19954-188] to IL-18 - BSA and Azide free.

Supplier: Apollo Scientific

1,3-Dimethyl-5-(prop-2-en-1-yloxy)-1H-pyrazole-4-carbaldehyde 95%

Supplier: Abcam

Rabbit monoclonal [EPR20715-16] to IL-1 alpha - BSA and Azide free (Capture).

Supplier: Apollo Scientific

Diethyl 2-{[(1,3-dimethyl-1H-pyrazol-5-yl)amino]methylidene}malonate

Supplier: Abcam

Rabbit monoclonal [EPR18536-15] to C Reactive Protein - BSA and Azide free (Detector).

Supplier: Abcam

Rabbit monoclonal [EPR17283-119] to IL-16 - BSA and Azide free (Capture).