48663 Results for: "GASTEC&pageNo=8"

AACOCF3 is a trifluoromethylketone derivative of arachidonic acid. It is a selective inhibitor of human cytosolic PLA2 and Ca2+-independent PLA2 (iPLA2, IC50=15 µM). It is active in intact platelets and U937 cells (IC50=8 µM). It also inhibits fatty acid amide hydrolase (100% at 7.5 µM).

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(±)-Propranolol hydrochloride ≥98% (by HPLC)

Supplier: Enzo Life Sciences

Propranolol blocks PLD derived DAG formation by inhibiting phosphatidate phosphohydrolase (IC50=70 µM). It is a useful tool to discriminate between PLC or PLD mediated DAG production. It is also a β-adrenergic receptor blocking agent.

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IM-12 ≥98% (by HPLC)

Supplier: Enzo Life Sciences

IM-12 ≥98% (by HPLC)

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(±)11,12-Epoxyeicosa-5Z,8Z,14Z-trienoic acid ≥98%

Supplier: Enzo Life Sciences

Biosynthesis via liver and renal cytochrome P-450. Induces glucagon release from pancreatic islets. Vasodilator in intestinal microcirculation. Inhibits Na+K+-ATPase. Urinary excretion in humans is increased during pregnancy-induced hypertension.

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Esculetin ≥98%

Supplier: Enzo Life Sciences

Lipoxygenase inhibitor

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Oleyloxyethyl phosphorylcholine ≥98% (by HPLC)

Supplier: Enzo Life Sciences

A potent and specific substrate analog PLA2 inhibitor (IC50=6.2 µM-porcine pancreatic PLA2). It inhibits human recombinant sPLA2 (IC50=13.7 µM) selectively over cPLA2. At 1 µM it completely blocked the myogenic response in perfused dog renal arcuate arteries.

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N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulphonamide ≥98% (by HPLC)

Supplier: Enzo Life Sciences

Cyclooxygenase inhibitor. Selectively inhibits PGH synthase-2 (IC50=1 µM) with no inhibition of PGH synthase-1 at concentrations up to 100 µM. Protects neuronal cultures from LPS-induced neurotoxicity.

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Tyrphostin AG 490 ≥98% (by TLC)

Supplier: Enzo Life Sciences

AG-490 is a potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. At 5 µM, AG-490 almost completely blocked the growth of all pre-B ALL cells but had no significant effect on the growth of mitogen-stimulated normal B or T cells, B-cell lymphoma or T-cell leukemia cells. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. It blocks interleukin-7-induced JAK kinase activity in T-cells (JAK-1, JAK-3) and the consequent phosphorylation of PI-3 kinase. AG-490 is cell permeable and is a valuable tool for studying the cellular role of JAK kinases in signal transduction.

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5-Iodotubercidin ≥98% (by TLC)

Supplier: Enzo Life Sciences

Inhibits ERK2 (Ki = 525nM). Also inhibits adenosine kinase (Ki = 30nM), CK1 and CK2 and insulin receptor kinase (IC50 ranging from 0.4-28µM).

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PP1 ≥98% (by TLC)

Supplier: Enzo Life Sciences

Src kinase inhibitor

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Manoalide ≥98% (by TLC)

Supplier: Enzo Life Sciences

Phospholipase inhibitor

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Fasudil dihydrochloride ≥98% (by TLC)

Supplier: Enzo Life Sciences

Inhibits Rho kinase (ROCK; Ki=0.33μM). Selective protein kinase A and G inhibitor (both Ki’s = 1.6μM). Inhibits agonist-induced activation of NADPH oxidase in human neutrophils (IC50=15μM). Inhibitor of myosin light chain kinase and Ca2+/calmodulin-dependent protein kinase II. Inhibits translocation of PKCβI, PKCβII and PKCζ. Cell permeable Ca2+ antagonist with antivasospastic properties.

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Decylubiquinone ≥98% (by TLC)

Supplier: Enzo Life Sciences

MPTP inhibitor

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Clopamide ≥98% (by HPLC)

Supplier: Enzo Life Sciences

Clinically useful diuretic. Clopamide selectively inhibits the chloride the sodium chloride cotransporter.

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URB-602 ≥98% (by TLC)

Supplier: Enzo Life Sciences

Selectively inhibits monoacylglycerol (MAG) lipase (IC50=28µM) via a noncompetitive mechanism. Does not inhibit FAAH, DAG lipase or COX-2. URB-602 selectively raises levels of 2-arachidonoylglycerol with no change in anandamide concentrationsin cells and tissues. In the same way anandamide levels were markely elevated by the FAAH inhibitor URB597 at 1µM.

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Exo1 ≥98%

Supplier: Enzo Life Sciences

ADP-ribosylation factor inhibitor

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Geldanamycin ≥98% Biotin

Supplier: Enzo Life Sciences

A useful tool for affinity purification of HSP-90 and HSP-90 dependent client proteins.

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QNZ ≥98%

Supplier: Enzo Life Sciences

NF-kappaB inhibitor

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ZM-306416 ≥98% (by TLC)

Supplier: Enzo Life Sciences

VEGF receptor tyrosine kinase inhibitor. Inhibits KDR (IC50=100nM) and Flt (IC50=2µM) tyrosine kinases.

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AM 580 ≥98% (by TLC)

Supplier: Enzo Life Sciences

Retinoic acid analog which acts as a selective RARα agonist with no affinity for RXRs. Induces differentiation in leukemia cell lines and inhibits angiogenesis in chick embryos.

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Isotetrandrine ≥98% (by TLC)

Supplier: Enzo Life Sciences

Phospholipase inhibitor

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all cis-5,8,11,14,17-Eicosapentaenoic acid ≥98% (by TLC)

Supplier: Enzo Life Sciences

Beneficial effect in cardiovascular diseases and inflammation. Inhibits PGE2 formation from arachidonic acid in 3T3 fibroblats.

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PD-146176 ≥98% (by HPLC)

Supplier: Enzo Life Sciences

A potent and selective 15-lipoxygenase inhibitor which lacks significant nonspecific antioxidant properties. It suppresses atherogenesis and limits atherosclerotic lesion development in the rabbit. It reduces oxidant stress-induced apoptosis in endothelial cells and inhibits proliferation in 15-LO overexpressing PC3 cells.