Supplier: Bioss

The adenovirus E1B protein is a viral homolog of the Bcl-2 family of proteins that are involved in regulating cell death. A family of interacting proteins, which are designated Nip or Bnip and include BNIP-1, BNIP-2, BNIP-3 and Nix, associate with both the E1B protein and Bcl-2 proteins to mediate apoptotic signaling. BNIP-1 contains a hydrophobic transmembrane domain, which enables its localization to the nuclear envelope, endoplasmic recticulum and mitochondria. BNIP-2, (previously designated Nip2 and Nip21 in human and mouse respectively), shares homology with the non-catalytic domain of Cdc42 GTPase-activating protein (Cdc42GAP). Through binding to Cdc42GAP, BNIP-2 enhances the GTPase activity of Cdc42GAP, facilitating the hydrolysis of GTP bound to Cdc42 and thereby, mediating the signaling pathways involving receptor kinases, small GTPases and apoptotic proteins. Nix, which is also designated Nip3L or Bnip3L, is highly related to BNIP-3, and both proteins localize to the mitochondria where they associate with Bcl-2 proteins. BNIP-3 preferentially binds to Bcl-xL and induces apoptosis by suppressing the anti-apoptosis activity of Bcl-xL.

Supplier: Bioss

CCDC19 is a 466 amino acid protein encoded by a gene mapping to human chromosome 1. Chromosome 1 is the largest human chromosome, spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1 and, considering the great number of genes, there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes Lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinson’s, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma.

Supplier: 3M

Designed with smart and intuitive features, the 3M™ Secure Click™ Half Mask Reusable Respirator is simple, comfortable and reliable. Available in three sizes: Small, medium and large. These respirators all come with an optional speaking diaphragm.

Supplier: Thermo Fisher Scientific

Use Thermo Scientific™ SureSTART™ 20 mm crimp caps with crimp vials that have a 20 mm opening, including our SureSTART 10 ml and 20 ml glass crimp top headspace vials (level 2). Select level 2 products for high-throughput applications, when robustness and reproducibility are key.

Supplier: FRISTADS KANSAS

Double-face sweatshirt made from 80% cotton and 20% polyester. Doubleface means that the outside of the fabric looks the same as the inside. The fabric is slightly stronger with an exclusive finish and long-lasting fit.

Supplier: FRISTADS KANSAS

Durable trousers made of Denim fabric (100% cotton), coloured back unwashed. Reinforcements in black 100% polyamide. With reflective piping at back for visibility.

Supplier: SIOEN

Modern, lightweight jacket made of 2-layer bonded softshell fabric consisting of 100% polyester stretch and 100% polyester fleece inside. The jacket provides good protection from cold and wind and can be be zipped into different jackets.

Supplier: FRISTADS KANSAS

Overalls made from 65% polyester and 35% cotton, with soft nap on reverse side.

Supplier: Portwest

Shirts with long sleeves made of 50% polyester and 50% cotton. The fabric offers warmth at all times.

Supplier: Biotium

PMA (propidium monoazide) dye is a DNA modifier invented by scientists at Biotium. It is a photo-reactive dye that binds to dsDNA with high affinity. Upon photolysis with visible light, PMA dye covalently attaches itself to dsDNA.

Supplier: FRISTADS KANSAS

Work trousers made ​​of 65% polyester and 35% cotton. With mechanical stretch and brushed inside. Material and knee pad pockets reinforced with Cordura®.

Supplier: MICRONOVA

The stainless steel Micronova BinLiner™ Stands™ are designed to work flawlessly with the BinLiners™ and similar sized bags. Securely hold a range of bin liner bags and feature two styles of open rod frames that allow ergonomic side removal of liners for simplified use.

Supplier: FRISTADS KANSAS

This robust and windproof two-colour jacket is made of 100% polyester and features a polyester lining. Ideal for people working in demanding industries.

Supplier: Rubbermaid Commercial Products

Safely collect waste wih touch-free closed lid containers.

Supplier: ProSci Inc.

PRPF19 plays a role in DNA double-strand break (DSB) repair and pre-mRNA splicing reaction. It binds double-stranded DNA in a sequence-nonspecific manner. PRPF19 acts as a structural component of the nuclear framework. It may also serve as a support for spliceosome binding and activity. It is essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. It also may have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Overexpression of PRPF19 might extend the cellular life span by increasing the resistance to stress or by improving the DNA repair capacity of the cells.In S. cerevisiae, Pso4 has pleiotropic functions in DNA recombination and in error-prone nonhomologous end-joining DNA repair.

Supplier: FRISTADS KANSAS

Work trousers made from 65% polyester and 35% cotton, in a luxury fabric. With rubber-free, elastic straps and adjustable waist.

Supplier: SIOEN

Protective, single colour jacket made of 100% soft double-sided polyester fleece providing good cold protection. With anti-pilling treatment and stitched seams.

Supplier: Corning

Axygen® ImpermaMat sealing mats minimize evaporation in a wide range of temperatures in PCR and storage applications. ImpermaMats are chemically resistant, reusable sealing mats, that provide a high degree of confidence.

Supplier: Avantor

Avantor® ACE® UltraCore SuperPhenylHexyl solid-core (core-shell) particle columns are ideal for demanding MS work offering improved MS signal intensity and maximum MS response. These stainless steel columns combine high efficiency separations with low column back pressure. The Encapsulated Bonding Technology (EBT™) greatly increases the ligand coverage of the silica surface and effectively eliminates the effect of unbonded silanol groups on separations. This higher ligand coverage results in improved inertness, chromatographic performance and stability.

Supplier: OHAUS

A range of four-place balances that incorporate a touch screen, advanced weighing and proximity sensor technologies. The easy to use control unit can be mounted on a base, above a base on an optional column, on a wall, or remotely (up to 3 metres distance with an optional cable). The touch screen display, with universal icons and informative prompts, simplifies set-up functions and basic operation. The operator has the added choice to use proximity sensors for hands-free operation when handling sensitive samples. These balances have multiple application modes from basic weighing to SQC applications, together with short stabilisation times and optimised performance specifications.

Supplier: Avantor Fluid Handling

Versatile pumps for accurate fluid delivery – with an intuitive touch-screen interface.

Supplier: Avantor Fluid Handling

Versatile gear pump systems for high-accuracy fluid delivery - with an intuitive touch-screen interface.

Supplier: VWR Chemicals

The tightening of regulatory requirements and the increasing demands of QA/QC methodology is becoming more important across all market sectors. The demand for standards to support testing methods continues to increase, and this growth applies to water determination according to Karl Fischer. Avantor now offers a complete range of Karl Fischer water standards as CRMs to calibrate and monitor equipment and check test results.

Supplier: ProSci Inc.

C-C Motif Chemokine 3-Like 1 (CCL3L1) is a secreted protein that belongs to the intercrine beta (chemokine CC) family. CCL3L1 is a ligand for CCR1, CCR3 and CCR5. CCL3L1 binds to several chemokine receptors including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The processed form LD78-beta (3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. The copy number of this gene varies among individuals: most individuals have 1-6 copies in the diploid genome, although rare individuals have zero or more than six copies. The human genome reference assembly contains two full copies of the gene (CCL3L3 and CCL3L1) and a partial pseudogene. This record represents the more centromeric full-length gene.

Supplier: Portwest

Portwest WX3 contemporary workwear is designed to the highest standards and offer a solution for everyday activity and working environments. Constructed with cutting edge fabrics giving superior abrasion resistance and exceptional all-day comfort. The WX3 work trousers are made from durable poly-cotton canvas fabric and includes triple stitched seams and stretch panelling providing excellent comfort and flexibility.

Supplier: Portwest

This fleece jacket made of 100% polyester with anti-pilling finish offers great warmth and comfort to the wearer.

Supplier: FRISTADS KANSAS

Protective trousers made from 75% cotton and 25% polyester. The cotton/polyester fabric mix offers long lasting protection against open flames and sources of heat thanks to the flame-retardant used.

Supplier: Portwest

The comfortable B300 Roma sweatshirt is ideal for work wear or casual weekend wear. Made of 65% polyester and 35% cotton.

Supplier: AAT Bioquest

Covidyte™ TF670 is a peptide substrate containing 14 amino acid sequence (KTSAVLQSGFRKME) that can be cleaved by coronavirus proteases. The dark-FRET peptide contains Tide Quencher™ 5 (TQ5) as a quencher and Tide Fluor™ 5 (TF5) as a fluorescent donor on the N-and C-terminals respectively where the fluorescence of TF5 is effectively quenched by TQ5 when the peptide is intact. When the peptide is hydrolysed by coronavirus proteases, the TF5 fragment generates significantly enhanced fluorescence since its fluorescence is no longer quenched by TQ5. The activity of coronavirus proteases can be effectively monitored by the fluorescence intensity of TF5. Covidyte™ TF670 is a robust high throughput screening tool for searching inhibitors of coronavirus proteases. TQ5-TF5 pair has been proven to an extremely effective FRET pair for developing FRET protease substrates. Comparing to the commonly used EDANS substrates (such as Covidyte™ EN450), the TF670 substrate has much stronger and longer fluorescence that is less interfered by coloured compounds that often cause false positive hits.

Supplier: HORIBA

These waterproof meters can measure and display up to 11 parameters simultaneously with one single probe. Thanks to their rugged design and their field replaceable sensors they are ideal for outdoor use, for example, when testing ground or surface water. Their compact size and the hand strap enable one-handed operation.