5268 Results for: "ENZO LIFE SCIENCES"

Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP).
Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signalling enzyme in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins.
Within the cyclophilin family, there are several different proteins which show a high degree of homology including CyPA, CyPB and CyPC. CyPA, also termed CyP-18, is the most abundant and ubiquitous cyclophilin found in all vertebrate tissues and is present in T-cells.

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Anti-IP3 Receptor Type 1 Rabbit Polyclonal Antibody

Supplier: ENZO LIFE SCIENCES

Host: Rabbit

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Anti-FKBP12 Rabbit Polyclonal Antibody

Supplier: ENZO LIFE SCIENCES

Host: Rabbit

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Anti-CRADD Rabbit Polyclonal Antibody

Supplier: ENZO LIFE SCIENCES

RAIDD (RIP-associated ICH-1 homologous protein with a death domain) is an adaptor molecule that mediates the action of cysteine proteases involved in apoptosis. In human cell lines, the caspase-2 adaptor RAIDD interacts selectively with caspase-2 through its caspase recruitment domain (CARD) and leads to caspase-2-dependent death. RAIDD overexpression induced caspase-2, CARD- and caspase-9-dependent apoptosis of PC12 cells and sympathetic neurons. Apoptosis correlated with the formation of discrete perinuclear aggregates. Both death and aggregates required the expression of full-length RAIDD. It has been reported that activation of caspase-2 occurs in a complex that contains the death domain–containing protein PIDD, whose expression is induced by p53, and the adaptor protein RAIDD.

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Anti-PARP2 Rabbit Polyclonal Antibody

Supplier: ENZO LIFE SCIENCES

Host: Rabbit

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Anti-MMP9 Rabbit Polyclonal Antibody

Supplier: ENZO LIFE SCIENCES

Host: Rabbit

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Anti-MMP13 Rabbit Polyclonal Antibody

Supplier: ENZO LIFE SCIENCES

Host: Rabbit

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Anti-TLR7 Rabbit Polyclonal Antibody

Supplier: ENZO LIFE SCIENCES

Host: Rabbit

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E-64

Supplier: ENZO LIFE SCIENCES

E-64

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Anti-MDA Rabbit Polyclonal Antibody

Supplier: ENZO LIFE SCIENCES

MDA (Malondialdehyde) is a highly reactive three carbon dialdehyde produced as a byproduct of polyunsaturated fatty acid peroxidation and arachidonic acid metabolism. MDA readily combines with several functional groups on molecules including proteins, lipoproteins, and DNA. MDA modified proteins may show altered physico-chemical behavior and antigenicity. Antibodies to MDA will help to visualize the MDA-adducts.