10967 Results for: "4-Chloropyridine+hydrochloride&pageNo=21"

Supplier: Bioss

G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR21 is a 349 amino acid multi-pass membrane protein that functions as an orphan receptor and belongs to the GPR1 family. The gene encoding GPR21 maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, and Familial dysautonomia, are both associated with chromosome 9.

Supplier: Bioss

Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodelling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodelling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.

Supplier: Bioss

GPR120, a member of the rhodopsin family of G protein-coupled receptors (GPCRs), is a 377 amino acid protein which is expressed in the intestine. GPR120 is a receptor for unsaturated long-chain FFAs (free fatty acids). FFAs act as signaling molecules and are an important energy source. They also employ various physiological responses through their GPCRs. One such response occurs when dietary FFAs stimulate GPR120. This stimulation promotes the secretion of glucagon-like peptide 1 (GLP-1) in vivo and in vitro. GLP-1 belongs to the class of molecules known as the incretins, which are associated with insulin secreted from the pancreas as a result of food intake. GLP-1 also inhibits glucagon and gastric acid secretion and gastric emptying. Consequently, the role of GPR120 in the secretion of GLP-1 is critical in the treatment of diabetes.

Supplier: Bioss

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development.

Supplier: Bioss

Hephaestin is a single-pass type I membrane protein that belongs to the multicopper oxidase family of proteins. Hephaestin, a copper-dependant ferroxidase protein, is crucial for iron exiting intestinal enterocytes into the circulation. It mediates the movement of iron across the basolateral membrane in conjunction with ferroportin 1. This is an important link between iron and copper metabolism in mammalian systems, as copper deficiency leads to reduced hephaestin and reduced iron absorption resulting in anemia. Hephaestin can bind six copper ions per monomer and is regulated by the homeobox transcription factor CDX2. Increased levels of iron leads to an increase in CDX2 expression and thus Hephaestin. Hephaestin is primarily detected in the intestine, but is also expressed in colon, breast, bone trabecural cells and fibroblasts.

Supplier: Bioss

This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organisation. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.

Supplier: Bioss

Voltage-gated K+ channels in the plasma membrane control the repolarisation and the frequency of action potentials in neurons, muscles and other excitable cells. The KV gene family encodes more than 30 proteins that comprise the subunits of the K+ channels, and they vary in their gating and permeation properties, subcellular distribution and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming alpha subunits (KV), which include the KV1, KV2, KV3, KV4 and KV9 proteins, and accessory or KV-subunits that modify the gating properties of the coexpressed KV subunits. KV2.2 is a multi-pass membrane protein that regulates the voltage-dependent K+ permeability of excitable membranes. Its tail may be influential in the targeting of the channel to specific subcellular compartments and/or the regulation of channel activity.

Supplier: OMNIFIT

EZ SolventPlus™ columns are designed for maximum chemical compatibility. Borosilicate glass and PTFE construction, with Chemraz® o-rings and PTFE frits, only the most inert materials are present in the fluid path. ETFE end caps and fitting nuts ensure a chemically inert connection into and out of the system.

Supplier: AnD Instruments Ltd (A&D)

These compact and lightweight precision balances from A&D are designed to offer a cost effective solution, whilst still delivering great performance and quality.

Supplier: GLW

PP, natural or coloured, alphanumeric identifier.

Supplier: Thermo Scientific

Thermo Scientific TSG series solid door laboratory refrigerators offer quiet, intuitive operation with excellent temperature performance and an outstanding warranty, meeting the needs of a wide variety of professional users who need consistent, reliable performance without sacrificing usability or sustainability.

Supplier: FRISTADS KANSAS

Robust trousers for ladies, made from 65% polyester and 35% cotton, with soft nap on reverse side.

Supplier: ALSICO HIGHTECH

This cleanroom coveralls is made of Alsistrong® (98% polyester and 2% carbon). Suitable for the highest cleanroom classes ISO 4 to 9 or GMP classes A to D.

Supplier: Greiner Bio-One

PS, coated with poly-lysine. Poly-D-Lysine (PDL) and Poly-L-Lysine (PLL) are synthetic molecules that are used to improve the adhesion of different cell types to polystyrene surfaces. The cultivation efficiency of individual cell lines can be improved, especially when serum-free or serum-reduced medium is used, or when experiments such as transfections are performed. As the PDL is synthetic it is free of the impurities carried by other proteins.

Supplier: FRISTADS KANSAS

Two-tone shorts with contrasting seams, made from 65% polyester and 35% cotton. Ideal for craftsmen and light industries.

Supplier: Edmund Bühler GmbH

Bench-top orbital shaker with heating plate which is suitable for mixing of difficult media. This shaker is the ideal solution when the use of an incubator hood is not possible due to the use of solvents (as solvents could destroy electrical parts and other materials of the incubator hood). The unit features digital display of set and actual values and programmable control.

Supplier: FRISTADS KANSAS

Cold resistant and water-repellent softshell jacket made of 100% windproof and breathable polyester stretch, Backing is made of 100% polyester microfleece. Reinforced with 100% polyamide.

Supplier: MACHEREY-NAGEL

These quantitative filter papers are made from refined pulp and linters. They are purified in a highly developed clean-up process to remove organic and inorganic impurities. This ensures a low ash content of <0,01 %. They are consistent performance and give safe results in gravimetric analyses.

Supplier: VARIAN

Bond Elut™ C18 is the most hydrophobic, bonded silica sorbent in the Bond Elut™ range. It is the most popular SPE sorbent because of its extremely retentive nature for non-polar compounds. C18 is generally regarded as having the broadest spectrum of retention among bonded silica sorbents, since it retains most organic analytes from aqueous matrices. When analysing small to intermediate molecules, Bond Elut™ C18 can be used for desalting aqueous matrices prior to ion exchange, as salts pass through the sorbent unretained.

Supplier: HAMILTON BONADUZ

The PRP-X100 is a polymeric column packing for separation of inorganic and organic anions from 10 to 500 ppm. These columns can be used to separate ions at concentrations from 1 to 1000 ppm without suppression or elaborate preconcentration techniques. The highly inert polymeric support resists chemical attack from organic solvents and aqueous buffers (0 - 100% aqueous or organic; pH 1 to 13), effectively lengthening column life.

Supplier: MICROSOLV

Cogent TYPE-C Silica™ is HPLC grade silica with a silica hydride surface. Their unique stationary phase will adsorb and desorb solvents commonly used in mobile phases very differently from ordinary silica resulting in excellent benefits to the chromatographer. Excellent for normal phase chromatography and solvent drying is not needed.

Supplier: OHAUS

Váhy Scout® STX jsou díky snadné navigaci pomocí barevného dotykového displeje ideální volbou pro laboratorní a průmyslové aplikace, zároveň jsou díky nízkému profilu a volitelnému skladovacímu krytu nenáročné na prostor.

Supplier: ProSci Inc.

Calcitonin is a secreted protein which belongs to the calcitonin family. Calcitonin is cleaved into the following two chains: Calcitonin and Katacalcin. Katacalcin is a potent plasma calcium-lowering peptide. Calcitonin is a 32-amino acid linear polypeptide hormone. Calcitonin acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH). Its importance in humans has not been as well established as its importance in other animals, as its function is usually not significant in the regulation of normal calcium homeostasis. Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.

Supplier: Thermo Scientific

Thermo Scientific TSG series glass door laboratory refrigerators offer quiet, intuitive operation with excellent temperature performance and an outstanding warranty, meeting the needs of a wide variety of professional users who need consistent, reliable performance without sacrificing usability or sustainability.

Supplier: TOSOH Bioscience

SkillPak™ BIO pre-packed columns are designed for a fast method development and scale-up of multi-column chromatography (MCC) or continuous chromatography processes. They are pre-packed with TOYOPEARL® process chromatography media for bioseparations.

Supplier: Ahlstrom-Munksjö

Ahlstrom-Munksjö’s qualitative grades of filter paper are recommended for use in analytical methods which determine or identify particulate constituents of a mixture irrespective of the amount present. Qualitative filter papers are often used in routine separation work that still requires high purity and consistent performance. These filter papers covers a wide range of laboratory applications, as liquids clarification, qualitative analytical separations for precipitates and buffers filtration, and are also used for soil analysis and in food and beverage testing. Standard qualitative filter papers are suitable for quadrant folded or gravity flow applications.

Supplier: GA

Permanent cryogenic laser labels for long-term storage in liquid phase and vapor phase liquid nitrogen (−196 °C), lab freezers (−80 °C), and on dry ice. Supplied in A4 sheet format for printing in standard desktop laser printers, these cryogenic labels do not jam printers and withstand UV and gamma irradiation.

Supplier: SIOEN

Lightweight, modern softshell jacket for protection against the cold. The jacket is made of two-layer bonded softshell (100% polyester stretch) on the outside and 100% polyester fleece on the inside.

Supplier: MICRONOVA

A range of lightweight, snap-on flat head mop covers with urethane foam interiors, designed for effective cleaning and sanitising in the cleanroom. A variety of fabric options provide excellent absorbency, effective cleaning, and disinfectant dispersal for specialised cleaning.

Supplier: MACHEREY-NAGEL

NUCLEODUR® C18 ec is a medium density monomeric octadecyl modified silica phase for HPLC.