Supplier: ProSci Inc.

This mAb recognises full-length MUC1/Mucin-1/Epithelial Marker Antigen/EMA in a glycosylation-independent manner and can bind to the fully glycosylated protein. The dominant epitope of this mAb is APDTR in the VNTR region. It reacts with the core peptide of the MUC1 protein, which is a member of a family of mucin glycoproteins that are characterised by high carbohydrate content, O-linked oligosaccharides, high molecular weight (>200 kDa) and an amino acid composition rich in serine, threonine, proline and glycine. The core protein contains a domain of 20 amino-acid tandem repeats that functions as multiple epitopes for the mAb. Incomplete glycosylation of some tumor-associated mucins may lead to variable unmasking of the multiple peptide epitopes leading to the observed differences in staining intensity between normal and malignant tissues. This mAb reacts with both normal and malignant epithelia of various tissues including breast and colon.

Supplier: ProSci Inc.

It recognises an intra-cytoplasmic antigen, which shows a very high degree of specificity for plasma cells. This antigen is present in normal as well as neoplastic plasma cells. Plasma cells, which are large lymphocytes derived from an antigen-specific B cell, secrete antibodies and are responsible for humoral immunity. Plasma cells differentiate from B cells upon stimulation by CD4+ lymphocytes. The B cell acts as an antigen-presenting cell (APC), consuming an offending pathogen, which is taken up by the B cell by phagocytosis and broken down within proteosomes. Plasma cells contain basophilic cytoplasm; their nucleus contains heterochromatin organized in a characteristic cartwheel arrangement. This mAb superbly recognises normal and neoplastic plasma cells in routine formalin-fixed, paraffin-embedded tissue sections. It is of potential value in identifying myeloma or plasmacytoma in bone marrow or other tissues. It also helps differentiate lympho-plasmacytoid lymphoma from lymphocytic and follicular lymphoma.

Supplier: ProSci Inc.

Recognises a protein of 47-55 kDa, which is identified as FOXP3. Its precise epitope is not known, but it has been mapped to the N-terminal portion of the protein. The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX, a fatal, X-linked inherited disorder characterised by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation.

Supplier: ProSci Inc.

Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). Cytokeratin 8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibody that recognises only cytokeratin 8 and 18. Cytokeratin 8 exists on several types of normal and neoplastic epithelia, including many ductal and glandular epithelia such as colon, stomach, small intestine, trachea, and esophagus as well as in transitional epithelium. Antibody to Cytokeratin 8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against Cytokeratin 8, 18 and 19). Reportedly, Cytokeratin 8 antibody is useful for the differentiation of lobular (“ring-like, perinuclear”) from ductal (“peripheral-predominant”) carcinoma of the breast.

Supplier: ProSci Inc.

A disulphide-linked heterodimer, consisting of mb-1 (or CD79a) and B29 (or CD79b) polypeptides, is non-covalently associated with membrane-bound immunoglobulins on B cells. This complex of mb-1 and B29 polypeptides and immunoglobulin constitute the B cell Ag receptor. CD79a first appears at pre B cell stage, early in maturation, and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B cell type, in B cell lines, B cell lymphomas, and in some myelomas. It is not present in myeloid or T cell lines. Anti-CD79a is generally used to complement anti-CD20 especially for mature B-cell lymphomas after treatment with Rituximab (anti-CD20). This antibody will stain many of the same lymphomas as anti-CD20, but also is more likely to stain B-lymphoblastic lymphoma/leukemia than is anti-CD20. Anti-CD79a also stains more cases of plasma cell myeloma and occasionally some types of endothelial cells as well.

Supplier: MP Biomedicals

Murashige and Skoog plant salt mixture without agar is a widely used plant tissue culture growth medium.

Supplier: ProSci Inc.

Adiponectin is a secreted protein. It is Synthesised exclusively by adipocytes and secreted into plasma. Adiponectin is an important adipokine that is involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Adiponectin Stimulates AMPK phosphorylation and activates in the liver and the skeletal muscle, enhancing glucose utilisation and fatty-acid combustion. Adiponectin also antagonises TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. It inhibits endothelial NF-kappa-B signalling through a cAMP-dependent pathway. Adiponectin may play a role in cell growth, angiogenesis and tissue remodelling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex: LMW, MMW or HMW.

Supplier: EPPENDORF

Eppendorf microplates provide exceptional stability during centrifugation with g-Safe® technology and efficient sample identification with the OptiTrack® Matrix. The design features, including RecoverMax® well design and raised well rims, ensure reliable sealing and facilitate maximum sample recovery.

Supplier: Antibodies.com

Porcine BNP ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of porcine BNP in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: Antibodies.com

Bovine BNP ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of bovine BNP in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: Antibodies.com

Human BNP ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human BNP in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: Antibodies.com

Rat BNP ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of rat BNP in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: DIVERSIFIED BIOTECH

Microplate seal, Adhesive film/foil/tape (96/384 wells), Single sheet/mat/strip, Breathe-Easy pre-cut, self-adhesive sheets, Sealing film for cell culture plates, Breathe-Easy, PU, Sterile

Supplier: BURKLE

These paddle wheel flow indicators give a clear visualisation of the flow rates of liquids or gas in tubing.

Supplier: Thermo Fisher Scientific

Pierce™ Graphite spin columns improve phosphopeptide analysis by efficiently binding hydrophilic peptides and efficiently removing urea, salts and other contaminants before mass spectrometry analysis.

Supplier: Abnova

mouse monoclonal antibody raised against PTPRC.

Supplier: Abnova

Mouse monoclonal antibody raised against recombinant PGR.

Supplier: Abnova

Mouse monoclonal antibody raised against EPCAM.

Supplier: EDVOTEK

Students can solve a crime using PCR. Plasmid DNA is provided that, when amplified by PCR, provides products that represent individual DNA profiles.

Supplier: Merck

Materials for the precise calibration and monitoring of pH meters.

Supplier: Medicom

ISO AIR cleanroom masks with duckbill feature a large and comfortable breathing chamber.

Supplier: Antibodies.com

Rabbit polyclonal antibody to OR1L6 for WB, IF and ELISA with samples derived from human.

Supplier: Antibodies.com

Rabbit polyclonal antibody to CLCA4 for WB with samples derived from human and rat.

Supplier: Antibodies.com

Rabbit polyclonal antibody to RPA30 for WB and ELISA with samples derived from human.

Supplier: Antibodies.com

Rabbit polyclonal antibody to EMSY for WB and ICC/IF with samples derived from Human and Mouse.

Supplier: AAT Bioquest

Designed for consistent and dependable results. The Cell Navigator™ Flow Cytometric Exosome Staining Kit addresses these challenges by enabling the detection of CD9-positive exosomes in purified or bead-bound samples.

Supplier: Thermo Fisher Scientific

Applications: Endogenous opioid peptide that also functions as a growth factor on many cell types at a receptor that is distinct from the neuronal opioid receptors.

Supplier: CENTURION SAFETY PRODUCTS

These vented safety helmets are made of HDPE. They are available with or without wheel ratchet.

Supplier: Thermo Fisher Scientific

Azadibenzocyclooctyne-PEG4-NHS ester (ADIBO-PEG4-NHS ester) is applied for protein-peptide conjugation, peptide-small molecule conjugation, 18F radiolabeling, protein-oligonucleotide conjugation and surface modification.

Supplier: SciLabware

PYREX®, Borosilicate glass.