97398 Results for: "4,16-Dibromo[2.2]paracyclophane&pageNo=9"
Tyrphostin AG-126 ≥98% (by HPLC)
Supplier: Enzo Life Sciences
AG-126 prevents lipopolysaccharide-induced lethal toxicity (septic shock) in mice. Administered at 1.5 mg/mouse, it reduced LPS-induced lethal toxicity from 95% to 10%. AG-126 greatly reduces LPS-induced tyrosine phosphorylation of p42MAPK in murine peritoneal macrophages at 50 µM. EGFR, Her-2/neu receptor or PDGF-R are not inhibited at 100 µM. Inhibits tyrosine kinase-dependent B cell receptor signaling.
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MK-886 ≥98% (by HPLC)
Supplier: Enzo Life Sciences
Inhibitor of PPARα activation. Inhibits 5-lipoxygenase-activating protein (FLAP) and leukotriene biosynthesis. Binds to FLAP with high affinity and prevents the activation of 5-lipoxygenase. IC50’s for leukotriene biosynthesis: 2.5 nM in intact leukocytes; 1.1 µM in whole blood. Induces apoptosis through the mitochondrial pathway.
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Gö 6983 ≥95% (by HPLC)
Supplier: Enzo Life Sciences
PKC inhibitor. Has been shown to selectively inhibit several PKC isoenzymes (IC50 = 7nM for PKCα and PKCβ; 6nM for PKCγ; 10nM for PKCδ; 60nM for PKCζ). The compound does not effectively inhibit PKCµ (IC50=20 µM) and therefore can be used to differentiate PKCµ from other isoforms.
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Tyrphostin A25 ≥99%
Supplier: Enzo Life Sciences
A potent inhibitor of EGF receptor kinase activity (IC50=3 µM).
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HNMPA-(AM)3 ≥98% (by TLC)
Supplier: Enzo Life Sciences
HNMPA-(AM)3 is a cell-permeable analog of HNMPA. It inhibits insulin receptor tyrosine kinase activity (IC50=100 µM) and insulin-stimulated glucose oxidation in isolated rat adipocytes (IC50=10 µM). It has no effect on PKA (at concs. up to 1 mM) or PKC (at concs. up to 420 µM). Inhibits both serine and tyrosine autophosphorylation by the human insulin receptor. Does not affect protein kinase C (PKC) or cAMP-dependent protein kinase (PKA).
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K-252b ≥98% (by HPLC)
Supplier: Enzo Life Sciences
General, cell permeable protein kinase inhibitor. Acts by binding to the ATP binding domain of the kinase. Potent inhibitor of Ca2+/calmodulin kinase II. Inhibits myosin light chain kinase (MLCK; Ki=0.147µM), cAMP- dependent protein kinase (PKA; Ki=0.09µM), protein kinase C (PKC; Ki=0.02µM), and cGMP-dependent protein kinase (PKG; Ki=0.1µM).
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3-Azaspiro[5.5]undecane hydrochloride ≥97% (by HPLC)
Supplier: Enzo Life Sciences
A novel member of the spiro-piperidine class of M2 proton channel inhibitors similar to BL-1743. Displays increased potency (IC50=0.92µM) compared with amantadine.
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Bongkrekic acid triammonium salt ≥92% (by HPLC)
Supplier: Enzo Life Sciences
Bongkrekic acid is an inhibitory ligand of the mitochondrial adenine nucleotide translocase. It inhibits mitochondrial permeability transition pore opening. At 50 µM it inhibits dexamethasone- apoptosis in thymocytes, preventing the PARP cleavage and DEVDase (caspase-3 like) activity normally produced by these treatments.
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Furoxan ≥99% (by HPLC)
Supplier: Enzo Life Sciences
A novel NO donor which only releases NO in the presence of thiols. It is a potent vasodilator and inhibitor of platelet aggregation.
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L-858051 ≥92% (by HPLC)
Supplier: Enzo Life Sciences
Adenylate cyclase activator.
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Sp-5,6-dichloro-cBIMPS ≥98% (by HPLC)
Supplier: Enzo Life Sciences
PKA activator.
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SB216763 ≥98% (by TLC)
Supplier: Enzo Life Sciences
Potent and selective inhibitor of GSK-3β (IC50=34nM). Stimulates glycogen synthesis in human liver cells and mimics other actions of insulin. Protects primary neurons from death induced by PI-3 kinase pathway inhibition suggesting therapeutic potential in neurodegenerative diseases and stroke. Reduces pulmonary inflammation and fibrosis in a mouse model.
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Sodium 4-phenylbutyrate ≥98% (by UHPLC)
Supplier: Enzo Life Sciences
Weak histone deacetylase (HDAC) inhibitor. Induces differentiation, growth arrest and apoptosis in a number of cell lines. Protects against cerebral ischemic injury and displays neuroprotective effect in a mouse model of Huntington’s disease. Anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation. Shows chemical chaperone activity.
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5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside ≥99% (by TLC)
Supplier: Enzo Life Sciences
AMPK activator
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2,3-Bis(2-hydroxyethylthio)-1,4-naphthalenedione ≥98% (by HPLC)
Supplier: Enzo Life Sciences
A potent and selective inhibitor of Cdc25 phosphatase (Ki's for Cdc25A, B and C are 32, 96 and 40 nM respectively). NSC-95397 inhibits the growth of several human tumor cell lines and blocks G2/M cell cycle transition.
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Ar231453 ≥98% (by HPLC), yellow solid
Supplier: Enzo Life Sciences
GPR119 activator.
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cis-5,8,11-Eicosatrienoic acid ≥97% (by HPLC), colourless oil
Supplier: Enzo Life Sciences
Immunomodulatory and anti-inflammatory effects.
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21-[4-(2,6-Di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]pregna-1,4,9[11]triene-3,20-dione maleate salt ≥98% (by TLC)
Supplier: Enzo Life Sciences
Blocks lipid peroxidation
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N-Arachidonylglycine ≥98% (by TLC)
Supplier: Enzo Life Sciences
FAAH inhibitor
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Geldanamycin ≥98% (by TLC) (conjugated to FITC)
Supplier: Enzo Life Sciences
A novel geldanamycin fluorescent probe that may be used in a fluorescence polarization assay for HSP90 inhibitors. May also be used for detection of cell surface HSP90.
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Midostaurin ≥98% (by TLC)
Supplier: Enzo Life Sciences
Inhibitor of a variety of serine/threonine and tyrosine kinases, like protein kinase C (PKC), cyclic AMP-dependent protein kinase (PKA), S6 kinase, Akt (protein kinase B; PKB), epidermal growth factor receptor (EGFR) tyrosine kinase activity and others including KDR, VEGFR, PDGFR, c-kit and other receptor tyrosine kinases. Potently inhibits FLT-3 kinase including mutant forms found in acute myeloid leukemia in vitro and in vivo. Apoptosis inducer. Showed broad antiproliferative activity against various tumor cell lines. Selectively inhibits T lymphocyte production of TNF-α. Upregulates endothelial nitric oxide synthase (eNOS; NOS III). Abrogates tumor angiogenesis in vivo.
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4,5,6,7-Tetrachloro-1H-indene-1,3(2H)-dione ≥95% (by TLC)
Supplier: Enzo Life Sciences
Novel inhibitor of ubiquitin C-terminal hydrolase L3 (IC50 = 0.6µM). Displays 125-fold greater selectivity over UCH-L1 (IC50 = 75µM).
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Ko143 ≥96% (by HPLC)
Supplier: Enzo Life Sciences
Analog of the fungal toxin fumitremorgin C. Potent and selective inhibitor of the breast cancer resistance protein multidrug transporter (BCRP, EC90=26nM). Highly effective for increasing the intracellular drug accumulation and reversing BCRP-mediated multidrug resistance yet has little activity against P-glycoprotein, multidrug resistance-associated protein (MRP1) and other known drug transporters. In mouse models Ko143 was able to restore the intracellular accumulation and abolish the directionality in net flux of dasatinib. It is a highly useful tool for the identification of drug transport processes in complex experimental systems.
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5,8,11,14-Eicosatetraynoic acid ≥98%
Supplier: Enzo Life Sciences
Arachidonic acid uptake inhibitor
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Chaetomellic acid A ≥98% (by TLC)
Supplier: Enzo Life Sciences
Potent inhibitor of farnesyltransferase in isolated enzyme assays (IC50=55nM) but is inactive in whole cells. Inhibition of farnesyltransferase is selective over geranylgeranyltransferase I and II (IC50=92µM and 34µM respectively).
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Lovastatin ≥98% (by TLC)
Supplier: Enzo Life Sciences
HMG-CoA reductase inhibitor
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NSC 23766 ≥99% (by HPLC)
Supplier: Enzo Life Sciences
Cell-permeable, reversible, and selective Rac1 inhibitor.
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Supplier: GRANT INSTRUMENTS
Supplier: BOCHEM
Supplier: VWR Collection
Supplier: OMEGA BIO-TEK
Supplier: DWK Life Sciences
Supplier: Thermo Fisher Scientific
Supplier: VWR Collection
Supplier: Oxford Nanopore Technologies
Supplier: Industrial Physics
Supplier: AAT BIOQUEST
Supplier: Integra
Supplier: Palbam
Supplier: VWR Collection
Supplier: Integra
Supplier: VWR Collection
Supplier: FACELLITATE
Supplier: NANOENTEK
Supplier: Greiner Bio-One