97398 Results for: "3-amino-4-(isopropylsulphonyl)thiophene-2-carboxylic+acid&pageNo=9"

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Ro 41-5253 ≥98% (by TLC)

Supplier: Enzo Life Sciences

Retinoic acid receptor ligand

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Endogenous [1] ligand for the CB1 receptor (CB1: Ki=52nm; CB2: Ki=1930nm [2]) and TRPV1 (Ki=5.78µM [3,4]). Inhibits NF-κB activation through direct binding to IKKβ [5] and induces apoptosis independently of cannabinoid or vanilloid receptors [6]. Activates the MAP kinase (MAPK/ERK) signalling pathway [7].

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Palmitoylethanolamide ≥98% (by TLC)

Supplier: Enzo Life Sciences

Endogenous cannabinoid. Weak ligand of CB1 (Ki=23.8µM) and CB2 (Ki=13.9µM) receptor. Inhibits fatty acid amide hydrolase (FAAH) (IC50=5.1µM). Immunosuppressant, anti-inflammatory, anti-nociceptive and anti-convulsant in vivo. The exact mode of action has not yet been revealed. It has been suggested that PEA: i) binds to a yet to be discovered cannabinoid receptor similar to CB2; ii) administered in vivo elicits the synthesis of endogenous agonists of CB2; iii) acts as an "entourage" compound by enhancing the activity and/or by influencing the turnover of endogenous agonists of CB2, possibly but not uniquely, by inhibiting their degradation.

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N-Arachidonoyl-L-phenylalanine ≥98% (by TLC)

Supplier: Enzo Life Sciences

Putative endogenous member of a growing family of lipo-amino acids (N-acyl amino acids).

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2-Arachidonoylglycerol ≥98% (by HPLC)

Supplier: Enzo Life Sciences

Cannabinoid receptor ligand.

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Eicosa-5Z,8Z-dienoic acid ≥98% (by TLC)

Supplier: Enzo Life Sciences

Arachidonic acid analog.

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3-Methyl-1-phenyl-2-pyrazolin-5-one ≥98% (by HPLC)

Supplier: Enzo Life Sciences

A free radical scavenger and antioxidant. Displays beneficial effects in a rat model of ischemic brain damage.

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N-Arachidonyl-2-chloroethylamide ≥98% (by TLC)

Supplier: Enzo Life Sciences

Cannabinoid receptor ligand.

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Virodhamine ≥98% (by TLC)

Supplier: Enzo Life Sciences

Cannabinoid receptor ligand.

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BML-283 ≥98% (by TLC)

Supplier: Enzo Life Sciences

Pyruvate kinase M2 activator.

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Ilimaquinone ≥98% (by TLC)

Supplier: Enzo Life Sciences

ADP-ribosylation factor inhibitor

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L-744,832 ≥98% (by TLC)

Supplier: Enzo Life Sciences

Ras farnesyltransferase inhibitor. Induces tumor regression in transgenic mice with multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Induces p21 expression and arrests cells at G1. Causes enhanced mitotic sensitivity to taxol.

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Farnesylthioacetic acid ≥98%

Supplier: Enzo Life Sciences

Methyltransferase inhibitor

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Mevastatin sodium ≥98% (by HPLC)

Supplier: Enzo Life Sciences

This is the active carboxylate form of mevastatin. It is active in whole cells as well as in cell free assays.

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WEB-2086 ≥98% (by HPLC)

Supplier: Enzo Life Sciences

PAF receptor antagonist. Inhibits PAF-induced human platelet and neutrophil aggregation in vitro (IC50=0.17 and 0.36µM respectively). In vivo it dose dependently blocks eosinophil activation and displays antiallergic and anti-inflammatory activity in various models. Induces differentiation and triggers apoptosis and in a variety of cell lines.

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PROTEASOME 19S RPT5/S6A SUBUNIT POLYCLONAL ANTIBODY 1 * 25 µl

Supplier: Enzo Life Sciences

PROTEASOME 19S RPT5/S6A SUBUNIT POLYCLONAL ANTIBODY 1 * 25 µl

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PROTEASOME 19S RPT1/S7 SUBUNIT MONOCLONAL ANTIBODY (MSS1-104) 1 * 100 µl

Supplier: Enzo Life Sciences

PROTEASOME 19S RPT1/S7 SUBUNIT MONOCLONAL ANTIBODY (MSS1-104) 1 * 100 µl

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PROTEASOME 19S RPN7/S10A SUBUNIT POLYCLONAL ANTIBODY 1 * 100 µl

Supplier: Enzo Life Sciences

PROTEASOME 19S RPN7/S10A SUBUNIT POLYCLONAL ANTIBODY 1 * 100 µl

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N,N,2-Trimethyl-5-nitrobenzenesulphonamide (synthetic) ≥98% (by TLC)

Supplier: Enzo Life Sciences

The first selective PDE7 inhibitor (Ki=180 nM).

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Gabexate mesylate ≥98% (by HPLC)

Supplier: Enzo Life Sciences

A competitive, reversible inhibitor of serine proteases tryptase (Ki=3.4nM), thrombin (Ki=500nM), uPA (Ki=1.3µM), plasmin (Ki=1.5µM), trypsin (Ki=2µM), factor Xa (Ki=2µM). At higher concentrations it inhibits kallikrein-1 (Ki=2.6mM), C1 esterase (IC50=520µM), as well as phospholipase A2 (IC50=500µM), rat iNOS (Ki=5mM) and cNOS (Ki=150µM), and swine kidney copper amine oxidase (Ki=27µM), but not chymotrypsin. Has been used in tissue culture and in vivo. In clinical use for pancreatitis.

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DL-Thiorphan ≥97% (by TLC)

Supplier: Enzo Life Sciences

Inhibits the metalloprotease neprilysin (neutral endopeptidase 24.11) and neprilysin 2. Inhibits opioid-degrading enzymes, potentiating THC-induced antinociception. Potentiates the effects of natriuretic peptides. Blocks enzymatic degradation of luteinizing hormone releasing hormone (LHRH).

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3,4-Dichloroisocoumarin ≥98% (by elemental analysis)

Supplier: Enzo Life Sciences

A potent irreversible mechanism based serine protease inhibitor. Inhibits granzymes A, B, and H, cathepsin G, neutrophil elastase and proteinase 3. Inhibits activation of neutral sphingomyelinase and apoptosis triggered by daunorubicin as well as camptothecin-induced apoptosis in HL-60 cells. Inhibits migration of eosinophils through basement membrane components in vitro.

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Argatroban ≥98% (by HPLC)

Supplier: Enzo Life Sciences

Argatroban is a synthetic peptidomimetic thrombin inhibitor which is in clinical use. It presents significant advantages as an anticoagulant in deep vein thrombosis, stroke prevention in atrial fibrillation and thromboembolic disease and especially in patients with coronary artery disease and heparin-induced thrombocytopenia.