30339 Results for: "2,2-Difluoroethyl+trifluoroacetate&pageNo=12&view=easy"

Supplier: Bioss

FAM84A is a 292 amino acid protein that belongs to the FAM84 family of proteins. Predominantly expressed in testis, FAM84A shares 44% amino acid identity with the related protein FAM84B. FAM84A localizes to a subcellular membrane region where there is no contact between neighboring cells and is believed to play a role in cell morphology and motility. More specifically, the expression of FAM84A increases cell motility. Two FAM84A isoforms are expressed due to alternative splicing events. Isoform 2 can be phosphorylated on various serine residues and this phosphorylation is associated with cellular morphology. FAM84A is upregulated in colorectal cancer, lung cancer, pancreatic cancer, cholangiocarcinoma and bladder cancer tissues. Via its ability to increase cell motility, FAM84A may contribute to the invasion and metastasis of cancer cells.

Supplier: Bioss

E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.

Supplier: Bioss

Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity.

Supplier: Thermo Fisher Scientific

These cryogenic vials have the same features as the standard cryotubes. They are designed for long term low temperature storage. Some vials have laser etched unique 2D barcodes that allow for tracking of the samples. The codes are permanently attached so they do not separate from the vials. Barcoded vials feature standard microplate format racks.

Supplier: DuPont

Tychem® 6000 F overalls are made from a lightweight and durable fabric (<500 g per garment) consisting of a proprietary barrier film laminated to a heavy duty Tyvek® substrate. They offer excellent chemical permeation protection to an extensive range of chemicals, helping to protect personnel against numerous toxic industrial organic chemicals, highly concentrated inorganic chemicals (even under pressure), particulates, biohazards and certain chemical warfare agents.

Supplier: Bioss

May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kB activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.

Supplier: MILLIPORE

These centrifugal filter units can be used for a number of applications: concentration of biological samples containing antigens, antibodies, enzymes, nucleic acids, or microorganisms; purification of macromolecular components found in tissue culture extracts or cell lysates and protein removal prior to HPLS; concentration of dilute or pre-purified proteins from column eluents; desalting, buffer exchange and protein dialysis; size exclusion and protein fractionation.

Supplier: Portwest

These trousers are made of Bizweld™ fabric consisting of 100% cotton with a flame-resistant finish. The fabric offers excellent protection for welding and all other allied industries.

Supplier: FRISTADS KANSAS

Double face sweat jacket made from 80% cotton and 20% polyester. Ideal for outdoor activities.

Supplier: Agilent

High quality off-axis design ion lenses separate ions from photons and residual neutral material resulting in lower background noise in 7700/8800 ICP-MS systems.

Supplier: Showa

These cotton lined nitrile gloves provide excellent protection from a wide array of solvents, oils and acids.

Supplier: FRISTADS KANSAS

Outdoor jacket made of 100% anti-pilling fleece (polyester). Ideal for people who are in contact with customers on a daily basis, such as in service, retail, or distribution businesses.

Supplier: FRISTADS KANSAS

Overalls made from 65% polyester, 35% cotton, with soft nap on reverse side.

Supplier: ProSci Inc.

Nucleotides are involved in numerous biochemical reactions and pathways within the cell as substrates, cofactors, and effectors. Nudix hydrolases, such as NUDT12, regulate the concentrations of individual nucleotides and of nucleotide ratios in response to changing circumstances.Nucleotides are involved in numerous biochemical reactions and pathways within the cell as substrates, cofactors, and effectors. Nudix hydrolases, such as NUDT12, regulate the concentrations of individual nucleotides and of nucleotide ratios in response to changing circumstances (Abdelraheim et al., 2003 [PubMed 12790796]).

Supplier: ERGOMAT

The Ergomat Softline is made from nitrile rubber and is designed to increase comfort while reducing tripping hazards, body aches, quality issues, and sick leaves. It is designed for areas where resistance to oil, petrochemicals and heat is important. Ideal for wet environments, in case of excessive volumes of fluids, the Softline can be die-cut to allow for drainage.

Supplier: Cytiva

Amersham™ Protran® Premium nitrocellulose blotting membranes provide excellent sensitivity, resolution and low background in fluorescence Western blotting detection applications.

Supplier: Antibodies.com

Bovine Lactoferrin ELISA Kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of bovine Lactoferrin in serum, plasma, tissue homogenates, cell lysates, saliva, milk, cell culture supernates or other biological fluids.

Supplier: Antibodies.com

Human ABCC12 ELISA Kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human ABCC12 in serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Supplier: LEICA MICROSYSTEMS

The Leica DM IL is a fluorescence-ready digital imaging solution designed for use in a variety of laboratory settings including cell culture, micromanipulation, immuno staining and routine live imaging.

Supplier: S.C.A.T.

The strong and electrically conductive safety funnel 'ARNOLD' V2.0 with lid and ball meets the highest requirements for safe disposal of hazardous liquid waste due to its combination of two independent safety mechanisms. The two safety features consist of a ball integrated in the funnel basin and a sealing ring incorporated in the hinged lid of the funnel, which prevent the escape of toxic gases. The funnel is especially designed for explosive or flammable substances, as the PE-HD material used is eclectically conductive and charges can be dissipated via the ground cable.

Supplier: VELP SCIENTIFIC

The MULTI-TX5 Digital is the ideal digital multi-tube vortex mixer for high sample throughput. The innovative and compact design ensures maximum operating comfort for mixing applications requiring different test tubes.

Supplier: Bioss

Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011].

Supplier: Bioss

Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity.

Supplier: Bioss

Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity.

Supplier: Bioss

FAM84A is a 292 amino acid protein that belongs to the FAM84 family of proteins. Predominantly expressed in testis, FAM84A shares 44% amino acid identity with the related protein FAM84B. FAM84A localizes to a subcellular membrane region where there is no contact between neighboring cells and is believed to play a role in cell morphology and motility. More specifically, the expression of FAM84A increases cell motility. Two FAM84A isoforms are expressed due to alternative splicing events. Isoform 2 can be phosphorylated on various serine residues and this phosphorylation is associated with cellular morphology. FAM84A is upregulated in colorectal cancer, lung cancer, pancreatic cancer, cholangiocarcinoma and bladder cancer tissues. Via its ability to increase cell motility, FAM84A may contribute to the invasion and metastasis of cancer cells.

Supplier: Bioss

FAM84A is a 292 amino acid protein that belongs to the FAM84 family of proteins. Predominantly expressed in testis, FAM84A shares 44% amino acid identity with the related protein FAM84B. FAM84A localizes to a subcellular membrane region where there is no contact between neighboring cells and is believed to play a role in cell morphology and motility. More specifically, the expression of FAM84A increases cell motility. Two FAM84A isoforms are expressed due to alternative splicing events. Isoform 2 can be phosphorylated on various serine residues and this phosphorylation is associated with cellular morphology. FAM84A is upregulated in colorectal cancer, lung cancer, pancreatic cancer, cholangiocarcinoma and bladder cancer tissues. Via its ability to increase cell motility, FAM84A may contribute to the invasion and metastasis of cancer cells.

Supplier: Merck

The selectivity offered by ZIC®-HILIC is suitable for a wide variety of molecules containing hydrophilic or ionisable functional groups. This includes compounds such as carbohydrates, metabolites, acids and bases, organic and inorganic ions, metal complexes, amino acids, peptides, protein digests, plant and cell extracts, plus much more. Such compounds are normally characterised by a small or negative LogP value and have poor retention on reversed-phase columns.

Supplier: FRISTADS KANSAS

These overalls with bib and braces are made from 65% polyester, 35% cotton, with a soft nap on reverse side.

Supplier: FRISTADS KANSAS

Working trousers made of 65% polyester and 35% cotton, with mechanical stretch. Brushed inside.

Supplier: Thermo Fisher Scientific

Using advanced low-retention technology, the hydrophobic inner surface of these tips significantly reduces sample loss to adhesion and maximises sample recovery. The tips are suitable for use when working with the most difficult samples, such as radioactive compounds, viscous materials, fragile cell lines, viruses, difficult proteins and PCR reagents.