48692 Results for: "2\'-Fluoro-2\'-deoxyinosine&pageNo=8"

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5(S)-Hydroxyeicosa-6E,8Z,11Z,14Z-tetraenoic acid (HETE) ≥98%

Supplier: ENZO LIFE SCIENCES

Biosynthesis via 5-lipoxygenase. Chemotactic and chemokinetic for PMNL. Induces degranulation and calcium flux.

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Cp 31398 Dihydrochloride (synthetic) ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

CP-31398 restores mutant p53 tumor suppressor function in vitro without affecting p53 homologs p63 and p73, and in vivo inhibiting UVB-induced skin carcinogenesis in mice. Stabilization of p53 inhibits ubiquitination without altering phosphorylation at Ser12 or Ser20 or MDM2 binding. Administration of this or similar compounds has the potential to enhance cytotoxic chemotherapy.

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Calpeptin ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

Calpain and cathepsin inhibitor

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3,4-Dichloroisocoumarin ≥98% (by elemental analysis)

Supplier: ENZO LIFE SCIENCES

A potent irreversible mechanism based serine protease inhibitor. Inhibits granzymes A, B, and H, cathepsin G, neutrophil elastase and proteinase 3. Inhibits activation of neutral sphingomyelinase and apoptosis triggered by daunorubicin as well as camptothecin-induced apoptosis in HL-60 cells. Inhibits migration of eosinophils through basement membrane components in vitro.

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Vinpocetine ≥98%

Supplier: ENZO LIFE SCIENCES

PDE inhibitor

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Zardaverine ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES

Selective, dual inhibitor of PDE III and PDE IV (IC50s=2.5 and 1.1 µM respectively). Anti-allergic activity, combined inhibition of PDE III and IV have an additive synergistic effect on inhibition of guinea pig bronchospasm.

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R-(-)-Rolipram ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES

R-enantiomer of rolipram which is more active at inhibition of PDE IV, Ki=06 µM. 10-fold more active than S-rolipram at inhibition of PDE IV. Inhibits antigen-induced contraction of guinea-pig colonic smooth muscle, EC50=0.1 µM.

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N,N,2-Trimethyl-5-nitrobenzenesulphonamide (synthetic) ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

The first selective PDE7 inhibitor (Ki=180 nM).

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Sivelestat sodium ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES

Potent and selective leukocyte elastase inhibitor (IC50=44nM). Displays various anti-inflammatory activities including attenuation of LTB4-induced neutrophil migration and serum cytokine levels. Reduces acute inflammatory lung injury in vivo.

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PF-356231 ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

Specific non-chelating small-molecule inhibitor of MMP-12 (IC50 = 14 nM). At higher concentrations it inhibits other MMPs, but spares MMP-1, making it a valuable tool for investigation of MMP activity and function.

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Gabexate mesylate ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES

A competitive, reversible inhibitor of serine proteases tryptase (Ki=3.4nM), thrombin (Ki=500nM), uPA (Ki=1.3µM), plasmin (Ki=1.5µM), trypsin (Ki=2µM), factor Xa (Ki=2µM). At higher concentrations it inhibits kallikrein-1 (Ki=2.6mM), C1 esterase (IC50=520µM), as well as phospholipase A2 (IC50=500µM), rat iNOS (Ki=5mM) and cNOS (Ki=150µM), and swine kidney copper amine oxidase (Ki=27µM), but not chymotrypsin. Has been used in tissue culture and in vivo. In clinical use for pancreatitis.

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Argatroban ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES

Argatroban is a synthetic peptidomimetic thrombin inhibitor which is in clinical use. It presents significant advantages as an anticoagulant in deep vein thrombosis, stroke prevention in atrial fibrillation and thromboembolic disease and especially in patients with coronary artery disease and heparin-induced thrombocytopenia.

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P32/98 ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES

DPPIV/DPP4 inhibitor

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Rotenone ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES

Rotenone ≥98% (by HPLC)

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Pseudohypericin ≥98% (by HPLC, TLC)

Supplier: ENZO LIFE SCIENCES

Inhibitor of PKC and dopamine beta-hydroxylase

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Manzamine A ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES

GSK-3 inhibitor

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R-sulphoraphane ≥98% (by UPLC)

Supplier: ENZO LIFE SCIENCES

Carciogenesis inhibitor

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Doxycycline hyclate ≥98% (dried basis)

Supplier: ENZO LIFE SCIENCES

MMP inhibitor

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Leptomycin B 0.2 mg/ml ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES

A potent and specific nuclear export inhibitor. In addition to antifungal and antibacterial activities, blocks the cell cycle and is a potent anti-tumor agent.