89401 Results for: "2\\\'-Methylbiphenyl-4-carboxylic+acid"

Supplier: Bioss

In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA ) and metabotropic (GABAB ) receptors as well as a third class of receptors called GABAC. In addition to GABA receptors, several proteins have been identified as regulators of GABA function, including GAD65, GAD67, GABA transporters and GABARAP (GABAA receptor-associated protein). GABARAP associates with GABAA Rg2 to link GABAA receptors to the cytoskeleton. The GABARAP protein sequence is similar to light chain-3 of microtubule-associated proteins (MAPs) suggesting that it may be a type of MAP or a component of a MAP complex.

Supplier: Bioss

In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA ) and metabotropic (GABAB ) receptors as well as a third class of receptors called GABAC. In addition to GABA receptors, several proteins have been identified as regulators of GABA function, including GAD65, GAD67, GABA transporters and GABARAP (GABAA receptor-associated protein). GABARAP associates with GABAA Rg2 to link GABAA receptors to the cytoskeleton. The GABARAP protein sequence is similar to light chain-3 of microtubule-associated proteins (MAPs) suggesting that it may be a type of MAP or a component of a MAP complex.

Supplier: Bioss

Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.

Supplier: Brand

Fixed volume or variable volume, analogue-adjustable or Digital Easy Calibration.

Supplier: Bioss

Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.

Supplier: Avantor

These Avantor® ACE® CN columns provide great reproducibility and column lifetime. These stainless steel columns are available in a wide range of particle sizes and dimensions from capillary to preparative.

Supplier: ProSci Inc.

Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 (4EBP1) is a number of the eIF4E-binding protein family. 4EBP1 regulates eIF4E activity by preventing its assembly into the eIF4F complex. 4EBP1 mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. Non-phosphorylated 4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E. 4EBP1 is phosphorylated in response to various signals including insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. 4EBP1 has a role in progression of breast neoplasms through cell signaling.

Supplier: MACHEREY-NAGEL

Photometric test kits for the determination of cyanide in water samples.

Supplier: Ansell

Medium-duty chemical barrier, Type 5/6 protection.

Supplier: Thermo Fisher Scientific

The Acclaim™ Trinity™ P1 is a unique, high-efficiency, silica-based column designed for pharmaceutical applications, such as simultaneous separation of pharmaceutical drug substances and their counterions.

Supplier: Bioss

TACC1 is one of three TACC family members, which are thought to be involved in breast tumorigenesis. TACC1 is located on 8p11 chromosomal region that is amplified in approximately 15% of all breast tumor samples. The short arm of chromosome 8 also contains FGFR1 whose expression is enhanced in most breast cancer tumors. TACC family members, TACC1, TACC2, and TACC3, map very closely to the corresponding FGFR1, FGFR2, FGFR3 genes on chromosomes 8, 10, and 4. Subsequently, since they are phylogenetically related, it is proposed that TACC and FGFR have similar roles in cell growth and differentiation. Also, TACC1 contains a conserved C-terminal region as in the Drosophila homolog, D-TACC. It has been shown that D-TACC is necessary for normal spindle function, and the mammalian TACC proteins appears to interact with centrosomes and microtubules in a similar manner

Supplier: ProSci Inc.

PPAPDC3 Antibody: PPAPDC3, also known as nuclear envelope transmembrane protein 39 (NET39), was initially discovered in an in silico screen for secreted or membrane proteins. It is a member of the PAP2 superfamily of phosphatases and haloperoxidases. PPAPDC3 has recently been shown to act as a negative regulator of myoblast differentiation by diminishing the activity of the mammalian target of rapamycin TOR. PPAPDC3 is highly expressed in cardiac and skeletal muscle and becomes strongly upregulated during cultured myoblast differentiation tissues. Overexpression of PPAPDC3 in myoblasts repressed myogenesis while knockdown by RNA interference promoted differentiation indicating its part in the regulatory mechanism for myogenesis.

Supplier: Corning

Axygen MaxyClear polypropylene microcentrifuge tubes feature exceptional clarity without compromising on strength.

Supplier: MILLIPORE

The MultiScreen384-SEQ filter plate is suited for use with most liquid handling systems. The filter plate operates by vacuum filtration enabling top-loading and recovery of sample. Our plate is designed with the needs of the high throughput laboratory in mind, meets SBS standards and is ideally suited for 'walk away' automation.

Supplier: MAPA

Liquid-proof latex glove with smooth or textured finish. Ideal for use in wet conditions.

Supplier: Marigold (Ansell)

These electrical insulating gloves are made from 100% natural rubber latex using a proprietary environmentally friendly dipping process for ultimate flexibility and dexterity.

Supplier: UVEX

These chemical protection gloves feature a thick cotton interlock lining and a full NBR coating (nitrile rubber). This makes the uvex rubiflex S suitable for many applications in which protection against chemicals and increased mechanical protection (for example against heat) is required.

Supplier: Avantor

Crystals. Lot analysis on label.

Supplier: UVEX

These chemical protection gloves are made from butyl rubber with a Viton® outer layer.

Supplier: MAPA

These fluoroelastomer gloves with textile lining are recommended for prolonged contact with aromatic solvents, sulphur-based chemicals and amines.

Supplier: Brand

Fixed volume or variable volume, analogue-adjustable or digital easy calibration.

Supplier: KIMBERLY CLARK

WypAll® L10 professional wiping paper products are designed for the specific environments where they will be used, helping enable you to deliver on your wiping task every time.

Supplier: Bioss

Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines residing in the dinucleotide CpG motif, and this methylation results in transcriptional repression of the target gene. The Dnmt enzymes are encoded by independent genes. Dnmt1 is the most abundant, and it preferentially methylates hemimethylated DNA and coordinates gene expression during development. Additional mammalian Dnmt proteins include Dnmt2 and Dnmt3. Dnmt2 lacks the large N-terminal regulator domain of Dnmt1, is expressed at substantially lower levels in adult tissues, and is likely involved in methylating newly integrated retroviral DNA. Dnmt3a and Dnmt3b are encoded by two distinct genes, but both are abundantly expressed in embryonic stem cells, where they also methylate CpG motifs on DNA.

Supplier: NEW PIG

This "Grab & go" spill response kit has a see-through design for easy inventory of spill response supplies.

Supplier: VWR Collection

Nobody has a perfectly symmetric morphology. This is why majority of people have back problems, sometimes with a feeling of heavy legs. The answer to this problem lies in the main features of this seat. Above all, a good working position is a dynamic posture that facilitates the bloodstream. The features of the seat help to re-balance the body naturally and improve blood flow in the legs. VWR® Ergonomic lab chairs and stools adapt automatically to the body and the movements of the user.

Supplier: Corning

PS. Designed to reduce well-to-well crosstalk during fluorescent and luminescent assays.

Supplier: Thermo Fisher Scientific

HisPur™ Ni-NTA resin is a high-capacity, high-performance nickel-IMAC resin for routine affinity purification of His-tagged fusion proteins.

Supplier: Thermo Fisher Scientific

These inhibitor tablets contain broad-spectrum protease inhibitors that are highly effective at preventing proteolytic degradation during cell lysis and protein extraction experiments.

Supplier: MACHEREY-NAGEL

Photometric test kit for the determination of carbonate hardness in water samples.

Supplier: Biotium

The most sensitive DNA gel stain available in convenient pre-coated agarose format with no need for post-electrophoresis staining.