Supplier: Bioss

C22orf31, also known as HS747E2A or bK747E2.1, is a 290 amino acid protein encoded by a gene located on human chromosome 22, which contains over 500 genes and about 49 million bases. As the second smallest human chromosome, chomosome 22 contains a wide variety of genes with numerous functions. Phelan-McDermid syndrome, Neurofibromatosis type 2 and autism are associated with chromosome 22. A schizophrenia susceptibility locus has been identified on chromosome 22 and studies show that 22q11 deletion symptoms include a high incidence of schizophrenia. Translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia Chromosome and the subsequent production of the novel fusion protein, BCR-Abl, a potent cell proliferation activator found in several types of leukemia.

Supplier: asecos

Fireproof safety cabinets, classified type 30 (fire resistant up to 30 minutes), safe, durable, robust and convenient with transport base and bicoloured cabinet design.

Supplier: Bioss

Chromosome 9 consists of about 145 million bases and 4% of the human genome and encodes nearly 900 genes. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterised by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias. The C9orf50 gene product has been provisionally designated C9orf50 pending further characterisation.

Supplier: Bioss

E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.

Supplier: Bioss

E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.

Supplier: Bioss

Nck is a highly conserved, oncogenic protein. It is a common target for the action of different surface receptors, encoding one SH2 and three SH3 domains, the Src homology motifs found in nonreceptor tyrosine kinases, Ras GTPase activating protein, phosphatidylinositol 3 kinase, and phospholipase Cg. Nck is widely expressed in various tissues and in cell lines from human, murine, and rat origins. Nck is phosphorylated on tyrosine, serine, and threonine residues in response to stimulation of EGF and PDGF in A431 and NIH 3T3 cells respectively. Like other SH2 containing proteins, Nck is associated with tyrosine autophosphorylated EGF or PDGF receptors via its SH2 domain. Overexpression of Nck leads to transformation of NIH 3T3 cells.

Supplier: Bioss

Nck is a highly conserved, oncogenic protein. It is a common target for the action of different surface receptors, encoding one SH2 and three SH3 domains, the Src homology motifs found in nonreceptor tyrosine kinases, Ras GTPase activating protein, phosphatidylinositol 3 kinase, and phospholipase Cg. Nck is widely expressed in various tissues and in cell lines from human, murine, and rat origins. Nck is phosphorylated on tyrosine, serine, and threonine residues in response to stimulation of EGF and PDGF in A431 and NIH 3T3 cells respectively. Like other SH2 containing proteins, Nck is associated with tyrosine autophosphorylated EGF or PDGF receptors via its SH2 domain. Overexpression of Nck leads to transformation of NIH 3T3 cells.

Supplier: Bioss

The Ca²⁺/calmodulin-dependent protein kinases (CaMKs) comprise a structurally related subfamily of serine/threonine kinases. CaMKI Beta (Ca²⁺/calmodulin-dependent protein kinase type 1B), also known as PNCK (pregnancy up-regulated non-ubiquitously expressed CaM kinase) or BSTK3, is a 343 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one protein kinase domain. Existing as multiple alternatively spliced isoforms, CaMKI Beta functions to catalyse the ATP-dependent phosphorylation of CaMKI, an event that activates CaMKI activity and may be important for Ca²⁺-triggered Signalling cascades within the cell. The gene encoding CaMKI Beta maps to human chromosome X, which contains nearly 153 million base pairs and houses over 1000 genes.

Supplier: Bioss

Chromosome 9 consists of about 145 million bases and 4% of the human genome and encodes nearly 900 genes. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterised by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias. The C9orf71 gene product has been provisionally designated C9orf71 pending further characterisation.

Supplier: Bioss

L glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

Supplier: LEICA MICROSYSTEMS

The objective lens is a critical part of the microscope optics. The microscope objective is positioned near the sample, specimen, or object being observed. It has a very important role in imaging, as it forms the first magnified image of the sample.

Supplier: FRISTADS KANSAS

Overalls made from 65% polyester, 35% cotton, with soft nap on reverse side.

Supplier: FRISTADS KANSAS

Tubular knit T-shirts made from 100% ring-spun cotton (single jersey). The grey melange shirt is made from 85% cotton and 15% viscose, while the yellow version is made from 65% polyester and 35% cotton.

Supplier: Corning

Corning® Nu-Serum™ IV is a growth medium supplement that provides a low-protein alternative to newborn calf, fetal bovine, and other sera routinely used for cell culture.

Supplier: Sartorius

These filter papers are used for routine analyses like clarification, determination of substances, but also as discs with a center hole for technical applications. Grades with a wet burst resistance >30 kPa are referred to as wet-strengthened and are therefore
suitable for pressure or vacuum filtration.

Supplier: ERGOMAT

The Ergomat Softline is made from nitrile rubber and is designed to increase comfort while reducing tripping hazards, body aches, quality issues, and sick leaves. It is designed for areas where resistance to oil, petrochemicals and heat is important. Ideal for wet environments, in case of excessive volumes of fluids, the Softline can be die-cut to allow for drainage.

Supplier: FRISTADS KANSAS

Gilets made from 65% polyester and 35% cotton; napped inner.

Supplier: FRISTADS KANSAS

Short trousers made of 65% polyester and 35% cotton, with soft nap on reverse side.

Supplier: MICROSOLV

RSA™ (Reduced Surface Activity) high quality and extremely consistent autosampler vials and caps due to reduced surface activity glass manufacturing and control processes. Excellent for low abundance or low dosage form analytes or samples that are pH sensitive, or basic in nature.

Supplier: Thermo Fisher Scientific

Natural tubes are made from 100% virgin PP to help ensure maximum clarity for biological-based work.

Supplier: Thermo Fisher Scientific

Contains a C4 linker which allows for superior alignment of the phenyl ring with aromatic molecules. Get excellent retention and unique selectivity for aromatic and moderately polar analytes with Thermo Scientific™ Hypersil GOLD™ Phenyl reversed phase HPLC columns.

Supplier: IKA

Typ N: Materiály v kontaktu s médiem jsou PTFE a nerezová ocel AISI 316L, vhodné pro rozpouštědla a abrazivní látky, lze sterilizovat všemi způsoby, max. teplota 180 °C.

Supplier: MACHEREY-NAGEL

NUCLEODUR® C8 ec is a medium density monomeric octyl modified silica phase for HPLC.

Supplier: FRISTADS KANSAS

This outdoor jacket is made of anti-pilling polyester, jersey bonded fabric, with micro fleece inside. The jacket is windproof, water repellent, breathable and quick drying.

Supplier: FRISTADS KANSAS

Vest made from 65% polyester and 35% cotton; napped inner.

Supplier: FRISTADS KANSAS

Functional vests made from 65% polyester and 35% cotton; with napped inner.

Supplier: Thermo Fisher Scientific

Ambient measurements or monitoring of laboratory equipment.

Supplier: VWR Collection

Kalhoty jsou vyrobeny z 99% polyesteru a 1% Hydro-Tec vlákna (obohacené uhlíkem). Díky tomuto speciálnímu vláknu s nanotechnologií Hydro-Tec je zajištěna extrémní pevnost, antistatické vlastnosti, ale také vynikající schopnost odpuzovat špínu, olej, chemikálie a vodu.

Supplier: VWR Collection

Sušárny VENTI-Line® jsou určeny pro veškeré standardní úlohy sušení a temperování, ale také sterilizaci laboratorního skla. Fungují v teplotním rozsahu od 50 do 300 °C a jsou určeny k použití v biologických, chemických, zdravotnických, farmaceutických a fyzikálních laboratořích.

Supplier: DUPERTHAL

Safety cabinets with storage shelves (CLASSIC line standard) or pull-out shelves (CLASSIC line pro) for the storage of hazardous substances in working spaces. Complete carcass, interior fittings and wing doors are made of powder-coated sheet steel.