30010 Results for: "1-(Chloromethyl)-4-nitro-1H-pyrazole&pageNo=12"

Supplier: Bioss

Differentiation of myogenic cells is regulated by multiple positively and negatively acting factors. One well characterized family of helix-loop-helix (HLH) proteins known to play an important role in the regulation of muscle cell development includes Myo D, myogenin, Myf-5 and Myf-6 (also designated MRF-4 or herculin). Myo D transcription factors form heterodimers with products of a more widely expressed family of bHLH genes, the E family, which consists of at least three distinct genes: E2A, IF2 and HEB. Myo D-E heterodimers bind avidly to consensus (CANNTG) E box target sites that are functionally important elements in the upstream regulatory sequences of many muscle-specific terminal differentiation genes. Both homo- and hetero-oligomers of these proteins are able to distinguish very closely related E box proteins and are believed to play important roles in lineage specific gene expression.

Supplier: Bioss

Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity.

Supplier: Enzo Life Sciences

Capases are a highly conserved family of cysteine proteases and are synthesized as inactive zymogens, which are cleaved at Asp-x sites during apoptosis, generating large and small subunits that heterodimerize to form the active enzyme. Caspase-1 is a member of the ICE/CED-3 family of caspases and is detected in the pro-form as a protein of 45 kDa.
Caspase-1 generates the bioactive form of the pro-inflammatory cytokine IL-1β from its biologically inactive precursor. Overexpression of caspase-1 in cells induces apoptosis, which can be inhibited by cytokine response modifier A (CrmA). Caspase-1 mRNA is predominantly expressed in the spleen and lung and to a lesser extent in skeletal muscle, kidney, testis and heart and within these tissues macrophages preferentially express caspase-1. Caspase-1 deficient mice have no gross abnormalities, however, macrophages from caspase-1-deficient mice are defective in IL-β processing and release.

Supplier: Bioss

Differentiation of myogenic cells is regulated by multiple positively and negatively acting factors. One well characterized family of helix-loop-helix (HLH) proteins known to play an important role in the regulation of muscle cell development includes Myo D, myogenin, Myf-5 and Myf-6 (also designated MRF-4 or herculin). Myo D transcription factors form heterodimers with products of a more widely expressed family of bHLH genes, the E family, which consists of at least three distinct genes: E2A, IF2 and HEB. Myo D-E heterodimers bind avidly to consensus (CANNTG) E box target sites that are functionally important elements in the upstream regulatory sequences of many muscle-specific terminal differentiation genes. Both homo- and hetero-oligomers of these proteins are able to distinguish very closely related E box proteins and are believed to play important roles in lineage specific gene expression.

Supplier: Portwest

Convenient for cooler weather, and ideal for workers in industries exposed to heat. The stylish design of the garment has a three-button placket, finished with a ribbed collar and cuffs.

Supplier: FRISTADS KANSAS

These overalls with bib and braces are made from 65% polyester, 35% cotton, with a soft nap on reverse side.

Supplier: HAMILTON BONADUZ

These venting needles are made of high grade stainless steel and are ideally suited for a wide range of applications. Various lengths and different hub connections are available to perfectly match the requirements of laboratory equipment manufacturers.

Supplier: Mettler - Toledo

This intuitive software for improved data management can be used with SevenCompact™, SevenCompact™ Duo, Seven2Go™ Pro, FiveEasyPlus or SevenExcellence™ pH meters. Within a few clicks the data measured on the pH meter can be seamlessly transferred to a computer. The application will store the data unmodified and allow for further printing or analysis.

Supplier: ProSci Inc.

RDH12 is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. RDH12 also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in this gene are a cause of Leber congenital amaurosis type 3 (LCA3).The protein encoded by this gene is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. The encoded enzyme also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in this gene are a cause of Leber congenital amaurosis type 3 (LCA3).

Supplier: Portwest

This 3-in-1 jacket is made of 100% nylon ottoman, with a breathable PU coating. The detachable fleece jacket is made of 100% anti pill polyester.

Supplier: SIOEN

Modern and lightweight outdoor jacket made of 2-layer bonded softshell (100% polyester stretch + 100% polyester fleece inside) with stitched seams. Provides good protection against cold temperatures and wind. The jacket can be zipped into the rain jacket 608Z for even better protection.

Supplier: Antibodies.com

Mouse RANK ELISA kit is a 90 minutes sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of mouse RANK in serum, plasma, and other biological fluids.

Supplier: Antibodies.com

Human IL-36R ELISA kit is a 90 minutes sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human IL-36R in serum, plasma, and other biological fluids.

Supplier: Antibodies.com

Mouse GDF7 ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of mouse GDF7 in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: Antibodies.com

Human Wnt5b ELISA kit is a 90 minutes sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human Wnt5b in serum, plasma, and other biological fluids.

Supplier: FRISTADS KANSAS

Windproof, bi-coloured jacket made of Airtech® fabric consisting of 100% polyester. The jacket features a quilt lining in the upper body and sleeves and an additional fleece lining for protection against cold.

Supplier: ProSci Inc.

PRDM12 belongs to PR-domain family which are involved in human cancers in an unusual yin-yang fashion. Two products are normally produced from a PR-domain family member which differ by the presence or absence of the PR domain; the PR-plus product is disrupted or underexpressed whereas the PR-minus product is present or overexpressed in cancer cells. This imbalance in the amount of the two products, a result of either genetic or epigenetic events, appears to be an important cause of malignancy. PRDM12 may have a potential role in the pathogenesis of chronic myeloid leukaemia with derivative chromosome 9 deletion.

Supplier: 3M Food Safety

The 3M™ Allergen Protein Rapid Kits are intended for screening for the presence of specific proteins in clean-in-place (CIP) final rinse water, environmental swab samples, food ingredients and processed food products.

Supplier: FRISTADS KANSAS

Thanks to their durability and comfort, these trousers are perfectly suitable for use in garages as well as in industrial and service companies. The material is made of 65% polyester and 35% cotton. The inside is brushed and provides a comfortable cotton feel. The outside is very hardwearing and does not bleach, even after countless washes.

Supplier: EPPENDORF

Eppendorf microplates provide exceptional stability during centrifugation with g-Safe® technology and efficient sample identification with the OptiTrack® Matrix. The design features, including RecoverMax® well design and raised well rims, ensure reliable sealing and facilitate maximum sample recovery.

Supplier: FRISTADS KANSAS

Thanks to their durability and comfort, these trousers are perfectly suitable for use in garages as well as in industrial and service companies. The material is made of 65% polyester and 35% cotton. The inside is brushed and provides a comfortable cotton feel. The outside is very hardwearing and does not bleach, even after countless washes.

Supplier: FRISTADS KANSAS

These highly visible jackets are made of 80% polyester and 20% cotton on the water-repellent outside. The other parts are made of 65% polyester and 35% cotton.

Supplier: Boster Bio

Rabbit IgG polyclonal antibody for Band 3 anion transport protein(SLC4A1) detection. Tested with WB, IHC-P, IHC-F in Human;Mouse;Rat.

Supplier: ProSci Inc.

NALP12 Antibody: NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kappa B activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.

Supplier: Portwest

Stylish, functional, and durable, the PW2 winter jacket offers protection and warmth in extreme weather conditions. Key features include contrast coloured panels for added style, an adjustable detachable hood, and plenty of pockets for storage.

Supplier: Antibodies.com

Human LTBP1 ELISA kit is a 90 minutes sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human LTBP1 in serum, plasma, and other biological fluids.

Supplier: Antibodies.com

Human RKIP ELISA kit is a 90 minutes sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human RKIP in serum, plasma, and other biological fluids.

Supplier: Antibodies.com

Human SRD5A1 ELISA kit is a 90 minutes sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human SRD5A1 in serum, plasma, and other biological fluids.

Supplier: Antibodies.com

Human SMOC2 ELISA kit is a 90 minutes sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human SMOC2 in serum, plasma, and other biological fluids.

Supplier: Antibodies.com

Human CYLC2 ELISA kit is a 90 minutes sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human CYLC2 in serum, plasma, and other biological fluids.