97398 Results for: "(Ethylthio)benzene&pageNo=9"

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2,3-Bis(2-hydroxyethylthio)-1,4-naphthalenedione ≥98% (by HPLC)

Supplier: Enzo Life Sciences

A potent and selective inhibitor of Cdc25 phosphatase (Ki's for Cdc25A, B and C are 32, 96 and 40 nM respectively). NSC-95397 inhibits the growth of several human tumor cell lines and blocks G2/M cell cycle transition.

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Ar231453 ≥98% (by HPLC), yellow solid

Supplier: Enzo Life Sciences

GPR119 activator.

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Ciglitazone ≥98%

Supplier: Enzo Life Sciences

PPAR ligand

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cis-5,8,11-Eicosatrienoic acid ≥97% (by HPLC), colourless oil

Supplier: Enzo Life Sciences

Immunomodulatory and anti-inflammatory effects.

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21-[4-(2,6-Di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]pregna-1,4,9[11]triene-3,20-dione maleate salt ≥98% (by TLC)

Supplier: Enzo Life Sciences

Blocks lipid peroxidation

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N-Arachidonylglycine ≥98% (by TLC)

Supplier: Enzo Life Sciences

FAAH inhibitor

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Geldanamycin ≥98% (by TLC) (conjugated to FITC)

Supplier: Enzo Life Sciences

A novel geldanamycin fluorescent probe that may be used in a fluorescence polarization assay for HSP90 inhibitors. May also be used for detection of cell surface HSP90.

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Midostaurin ≥98% (by TLC)

Supplier: Enzo Life Sciences

Inhibitor of a variety of serine/threonine and tyrosine kinases, like protein kinase C (PKC), cyclic AMP-dependent protein kinase (PKA), S6 kinase, Akt (protein kinase B; PKB), epidermal growth factor receptor (EGFR) tyrosine kinase activity and others including KDR, VEGFR, PDGFR, c-kit and other receptor tyrosine kinases. Potently inhibits FLT-3 kinase including mutant forms found in acute myeloid leukemia in vitro and in vivo. Apoptosis inducer. Showed broad antiproliferative activity against various tumor cell lines. Selectively inhibits T lymphocyte production of TNF-α. Upregulates endothelial nitric oxide synthase (eNOS; NOS III). Abrogates tumor angiogenesis in vivo.

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4,5,6,7-Tetrachloro-1H-indene-1,3(2H)-dione ≥95% (by TLC)

Supplier: Enzo Life Sciences

Novel inhibitor of ubiquitin C-terminal hydrolase L3 (IC50 = 0.6µM). Displays 125-fold greater selectivity over UCH-L1 (IC50 = 75µM).

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Ko143 ≥96% (by HPLC)

Supplier: Enzo Life Sciences

Analog of the fungal toxin fumitremorgin C. Potent and selective inhibitor of the breast cancer resistance protein multidrug transporter (BCRP, EC90=26nM). Highly effective for increasing the intracellular drug accumulation and reversing BCRP-mediated multidrug resistance yet has little activity against P-glycoprotein, multidrug resistance-associated protein (MRP1) and other known drug transporters. In mouse models Ko143 was able to restore the intracellular accumulation and abolish the directionality in net flux of dasatinib. It is a highly useful tool for the identification of drug transport processes in complex experimental systems.

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5,8,11,14-Eicosatetraynoic acid ≥98%

Supplier: Enzo Life Sciences

Arachidonic acid uptake inhibitor

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Chaetomellic acid A ≥98% (by TLC)

Supplier: Enzo Life Sciences

Potent inhibitor of farnesyltransferase in isolated enzyme assays (IC50=55nM) but is inactive in whole cells. Inhibition of farnesyltransferase is selective over geranylgeranyltransferase I and II (IC50=92µM and 34µM respectively).

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Lovastatin ≥98% (by TLC)

Supplier: Enzo Life Sciences

HMG-CoA reductase inhibitor

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NSC 23766 ≥99% (by HPLC)

Supplier: Enzo Life Sciences

Cell-permeable, reversible, and selective Rac1 inhibitor.

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ELISA KIT HUMAN TETANUS TOXOID IGG 1 * 96 Tests

Supplier: Enzo Life Sciences

ELISA KIT HUMAN TETANUS TOXOID IGG 1 * 96 Tests

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3,4-Di(1H-indol-3-yl)-1H-pyrrole-2,5-dione ≥98%

Supplier: Enzo Life Sciences

PKC inhibitor

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Aristolochic acid ≥97%

Supplier: Enzo Life Sciences

Reversible noncompetitive PLA2 inhibitor.

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Clofibrate ≥98% (by GC)

Supplier: Enzo Life Sciences

PPARα activator.

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Rosmarinic acid ≥98% (by HPLC)

Supplier: Enzo Life Sciences

Rosmarinic acid ≥98% (by HPLC)

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(-)-Epigallocatechin gallate ≥98% (by HPLC)

Supplier: Enzo Life Sciences

Inhibitor of NOS, telomerase and Dnmt

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Aminopurvalanol A ≥97% (by 1H-NMR)

Supplier: Enzo Life Sciences

CDK/cyclin inhibitor

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Ratjadone A (synthetic) ≥95%

Supplier: Enzo Life Sciences

Ratjadone A (synthetic) ≥95%

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Tryptanthrin ≥98% (by 1H-NMR, HPLC)

Supplier: Enzo Life Sciences

Inhibitor of prostaglandin and leukotriene synthesis.

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SC-236 ≥95% (by HPLC)

Supplier: Enzo Life Sciences

Highly selective and potent inhibitor of cyclooxygenase-2 (IC50=10nM for COX-2 versus IC50=17.8µM for COX-1) with antitumor properties. Exhibits longer half-life time and reduced gastric toxicity in fasting rat model. Has antitumor properties and has been shown to induce apoptosis and bFGF and VEGF-driven angiogenesis. Potent antimetastatic activity against both spontaneous metastases arising following primary tumour excision and experimental metastases.

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SB239063 ≥97% (by HPLC)

Supplier: Enzo Life Sciences

A potent, cell permeable inhibitor of p38 MAP kinase (IC50=44nM for recombinant purified human p38α). Inhibits IL-1 and TNF-α production in LPS-stimulated human peripheral blood monocytes (IC50=120nM and 350nM, respectively). Reported to protect against mild excitotoxic neuronal injury caused by NMDA and provides substantial protection against cell death induced by either oxygen glucose deprivation (OGD) or magnesium deprivation in cultured neurons. Also, reduces myocardial reperfusion injury via inhibition of endothelial adhesion molecule expression and blockade of polymorphonuclear (PMN) accumulation.