1297 Results for: "(1R)-(+)-\\\\u03B1-Pinene"

Supplier: Antibodies.com

Rabbit polyclonal antibody to CSFR for IHC, IF and ELISA with samples derived from Human, Mouse and Rat.

Supplier: AAT Bioquest

Gentamicin is widely used for treating tuberculosis and Gram-negative infections and is particularly useful in neonatal intensive care units. Fluorophore-tagged drugs, such as gentamicin-Texas Red (GTTR) conjugates, have been used to identify drug trafficking routes across the BLB and into hair cells, and specifically in the cochlea - the sensory organ responsible for hearing. Identifying the mechanisms involved in the intracochlear trafficking of ototoxic drugs to hair cells is of fundamental as well as clinical importance. Texas Red-gentamicin conjugate (GTTR) provides researchers a valuable tool to study the cellular uptake, kinetics and distribution of gentamicin through fluorescence techniques, such as fluorescence microscopy, fluorescence correlation spectroscopy, single molecule spectroscopy. The TR fluorophore can be conveniently excited from 500-600 nm, with an emission maximum centered around 610 nm. Acute nephrotoxicity and permanent ototoxicity are serious side-effects that increase patient morbidity, or induce permanent auditory and vestibular deficits. Several approaches have been used to study the intracellular mechanisms induced by ototoxic drugs. However, ototoxic drugs must first cross the blood-labyrinth barrier (BLB) before entering sensory hair cells to exert their cytotoxic effect that leads to hearing loss and deafness. The BLB is similar to the blood-brain barrier (BBB), and is composed of tight junction-coupled endothelial and epithelial barrier layers that transport nutrients and ions from one side of the barrier to the other.

Supplier: Antibodies.com

Rabbit polyclonal antibody to M-CSF Receptor (phospho Tyr723) for WB, IHC and ELISA with samples derived from Human, Mouse and Rat.

Supplier: Antibodies.com

Rabbit polyclonal antibody to CSFR (phospho Tyr561) for WB, IHC and ELISA with samples derived from Human, Mouse and
Rat.

Supplier: Antibodies.com

Rabbit polyclonal antibody to M-CSF Receptor (phospho Tyr723) for WB, IHC and ELISA with samples derived from Human, Mouse and Rat.

Supplier: ProSci Inc.

Interleukin-1 receptor type 2 (IL1R2) belongs to the interleukin-1 receptor family. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1 receptor type II is a 68 kDa transmembrane protein found on B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. IL1R2 is non-signalling receptor forIL1A, IL1B and IL1RN, reduces IL1B activities. IL1R2 serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signalling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

Supplier: ProSci Inc.

Interleukin-1 receptor type 2 (IL1R2) belongs to the interleukin-1 receptor family. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1 receptor type II is a 68 kDa transmembrane protein found on B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. IL1R2 is non-signalling receptor forIL1A, IL1B and IL1RN, reduces IL1B activities. IL1R2 serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signalling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralisation of IL1B by secreted/soluble receptors.

Supplier: Abcam

Human IL1R2 ELISA kit is a single-wash 90-min Simplestep used to quantify Human IL1R2 with a sensitivity of 24,96 pg/ml. The assay uses a simple mix-wash-read protocol with just one incubation and one wash step. - Colorimetric sandwich ELISA - 450 nm readout : works on any standard plate reader - Design your own immunoassay: we also offer the conjugation-ready antibody pair.

Supplier: Abcam

Recombinant human CSF-1-R protein is a Human Fragment protein, in the 539 to 972 aa range, expressed in Insect, with >85% purity and suitable for SDS-PAGE, FuncS.

Supplier: ProSci Inc.

Interleukin 1 receptor, type I (IL-1R1) is an interleukin receptor that belongs to the interleukin-1 receptor family. IL-1R1 is an 80 kDa transmembrane protein that is expressed predominantly by T cells, fibroblasts, and endothelial cells. This gene along with IL1R2, IL1RL2, and IL1RL1 form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. IL-1R1 is an important mediator involved in many cytokine induced immune and inflammatory responses. It binds to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. The signalling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. It also binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signalling complex. An IL1 receptor accessory protein that can heterodimerize with the Type I receptor in the presence of IL1 alpha or IL1β but not IL1ra, was identified. Recombinant IL1 soluble receptor Type I is a potent antagonist of IL1 action.

Supplier: Abcam

Recombinant Human CDK2AP2 protein is a Human Full Length protein, in the 1 to 126 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.

Supplier: ProSci Inc.

Mouse Interleukin 1 receptor, type II (IL1R2) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. IL-1R2 structurally consisting of a ligand binding portion comprised of three Ig-like domains, a single transmembrane region, and a short cytoplasmic domain. It is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Mouse IL1RII shares 59% amino acid sequence homology with human IL1 RII in their extracellular domains. The pleiotropic cytokine IL1 is produced to regulate development and maintenance of the inflammatory responses, and binds to specific plasma membrane receptors on cells. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R1 contributes to IL-1 signalling, whereas the IL-1R2 has no signalling property and acts as a decoy for IL-1.

Supplier: ProSci Inc.

Interleukin 1 receptor, type I (IL-1R1) is an interleukin receptor that belongs to the interleukin-1 receptor family. IL-1R1 is an 80 kDa transmembrane protein that is expressed predominantly by T cells, fibroblasts, and endothelial cells. This gene along with IL1R2, IL1RL2, and IL1RL1 form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. IL-1R1 is an important mediator involved in many cytokine induced immune and inflammatory responses. It binds to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. The signalling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. It also binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signalling complex. An IL1 receptor accessory protein that can heterodimerise with the Type I receptor in the presence of IL1 alpha or IL1β but not IL1ra, was identified. Recombinant IL1 soluble receptor Type I is a potent antagonist of IL1 action.

Supplier: Abcam

Recombinant human CSF-1-R protein is a Human Fragment protein, in the 20 to 512 aa range, expressed in HEK 293, with >95% purity, <1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS.

Supplier: Abcam

Recombinant Human CSF-1-R protein (Fc Chimera) is a Human Fragment protein, in the 20 to 517 aa range, expressed in Mammalian, with >95% purity, <1 EU/µg endotoxin level and suitable for SDS-PAGE.

Supplier: Abcam

Recombinant mouse CSF-1-R protein (Active) is a Mouse Fragment protein, in the 20 to 511 aa range, expressed in HEK 293, with >95% purity, <1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS.

Supplier: Abcam

Recombinant human NR1D2 / RVR protein is a Human Full Length protein, expressed in Baculovirus, with >95% purity and suitable for SDS-PAGE, GSA, EMSA.

Supplier: Abcam

Recombinant Mouse CSF-1-R Protein is a Mouse Fragment protein, in the 20 to 511 aa range, expressed in HEK 293, ≤0,005 EU/µg endotoxin level and suitable for SDS-PAGE, MS, HPLC.

Supplier: Abcam

Recombinant Mouse CSF-1-R Protein (Fc Chimera) (Active) is a Mouse Fragment protein, in the 20 to 511 aa range, expressed in HEK 293, with ≥95% purity and suitable for MS, HPLC, SDS-PAGE.

Supplier: ProSci Inc.

IL-18RAP is a single-pass type I membrane protein and contains two Ig-like C2-type domains and one TIR domain, IL18RAP can be induced by IFN-alpha and IL12 in nature killer cells and T-cells. The coexpression of IL18R1 and IL18RAP is required for the activation of NF-kappa B and JNK in response to IL-18.Defects in IL18RAP are associated with Coeliac disease.

Supplier: Abcam

Recombinant Human IL-1 RAcP/IL-1 R3 Protein 9 (His-tag) is a Human Fragment protein, in the 21 to 367 aa range, expressed in HEK 293, with ≥95% purity and ≤ 0.005 EU/µg endotoxin level.

Supplier: Abcam

Recombinant Human IL-1RAcP protein (His tag) is a Human Fragment protein, in the 21 to 359 aa range, expressed in HEK 293, with >95% purity, <1 EU/µg endotoxin level and suitable for SDS-PAGE.

Supplier: Abcam

Recombinant mouse CSF-1-R protein (Fc Chimera Active) is a Mouse Fragment protein, in the 20 to 511 aa range, expressed in HEK 293, with >95% purity, <0,1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS.

Supplier: Abcam

Recombinant Human SIGIRR protein (His tag) is a Human Fragment protein, in the 1 to 118 aa range, expressed in HEK 293, with >95% purity, <1 EU/µg endotoxin level and suitable for SDS-PAGE.

Supplier: Abcam

Recombinant Human IL-1RAcP protein is a Human Full Length protein, in the 21 to 356 aa range, expressed in HEK 293, with >95% purity, <1 EU/µg endotoxin level and suitable for SDS-PAGE, HPLC.

Supplier: Abcam

Recombinant Mouse SIGIRR protein (Fc Chimera His Tag) is a Mouse Fragment protein, in the 1 to 238 aa range, expressed in HEK 293, with >95% purity, <1 EU/µg endotoxin level and suitable for SDS-PAGE.

Supplier: ProSci Inc.

CDK2AP2, also known as DOC1R, is short for cyclin-dependent kinase 2-associated protein 2. The gene CDK2AP2 encodes this protein that interacts with cyclin-dependent kinase 2 associated protein 1. Pseudogenes associated with this gene are located on chromosomes 7 and 9. Alternatively spliced transcript variants have been observed for this gene. It belongs to the CDK2AP family. CDK2AP1 (cyclin-dependent kinase 2-associated protein 1), corresponding to the gene doc-1 (deleted in oral cancer 1), is a tumor suppressor protein. The doc-1 gene is absent or down-regulated in hamster oral cancer cells and in many other cancer cell types. The ubiquitously expressed CDK2AP1 protein is the only known specific inhibitor of CDK2, making it an important component of cell cycle regulation during G(1)-to-S phase transition.

Supplier: ProSci Inc.

Interleukin-1 Receptor Accessory Protein (IL-1RAcP) is a member of the interleukin-1 receptor family. It contains three Ig-like C2-type domains in the extracellular region and a long cytoplasmic domain implicated in signal transduction. IL-1RAcP acts as a non-ligand binding accessory component of the receptors for IL1 alpha, IL1 beta and IL33. IL-1RAcP mediates interleukin-1-dependent activation of NF-kappa-B. It is part of the membrane-bound form of the IL-1 receptor. IL-1 RAcP takes part in the Signaling ways by the formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2. In addition, IL-1RAcP modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor.

Supplier: ProSci Inc.

Interleukin-1 Receptor Accessory Protein (IL-1RAcP) is a member of the interleukin-1 receptor family. It contains three Ig-like C2-type domains in the extracellular region and a long cytoplasmic domain implicated in signal transduction. IL-1RAcP acts as a non-ligand binding accessory component of the receptors for IL1 alpha, IL1 beta and IL33. IL-1RAcP mediates interleukin-1-dependent activation of NF-kappa-B. It is part of the membrane-bound form of the IL-1 receptor. IL-1 RAcP takes part in the Signaling ways by the formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2. In addition, IL-1RAcP modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor.

Supplier: Antibodies.com

Human MCHR-1 ELISA Kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human MCHR-1 in tissue homogenates or other biological fluids.