An in vitro system for assessing the invasive potential of both malignant and normal cells.

• Proven biological performance using Corning® FluoroBlok™ PET membrane coated with Corning® Matrigel® matrix
• Allows for rapid and reproducible quantitation of tumour cell invasion in vitro
• Increase throughput for tumour cell invasion assays
• Allows automation of assays with simplified and non-destructive fluorescence detection
• Saves time and labour screening for prospective anti-metastatic compounds

Corning® BioCoat™ Matrigel® invasion chambers enable studies of metastatic potential of tumour cells; expression of matrix metalloproteinase on the surface of invasive tumour cells; inhibition of metastasis by ECM components or antineoplastic drugs (i.e. Taxol®); altered expression of cell surface proteins in metastatic cells; and invasion of normal cells, such as embryonic stem cells, cytotrophoblasts, and fibroblasts as well as of multiple cell lines. The Corning® BioCoat™ Matrigel® invasion chamber is an in vitro system for the study of cell invasion through the basement membrane. It consists of Falcon® cell culture inserts containing an 8,0 µm pore-size PET membrane coated with a uniform layer of Corning® Matrigel® matrix.

The Corning® BioCoat™ tumour invasion system is an in vitro system for the study of tumour cell invasion through the basement membrane. It consists of Corning® FluoroBlok™ multiwell insert plates containing an 8,0 µm pore size Corning® FluoroBlok™ membrane coated with a uniform layer of Corning® Matrigel® basement membrane matrix. The Corning® Matrigel® matrix occludes the pores of the Corning® FluoroBlok™ membrane, blocking non-invasive cells from migrating through the membrane.