Specifications
- Antibody type:Primary
- Antigen name:cytotoxic T-lymphocyte-associated protein 4
- Antigen symbol:Ctla4
- Clonality:Monoclonal
- Clone:UC10-4F10-11
- Conjugation:Unconjugated
- Flow cytometry:Yes
- Host:Hamster
- Isotype:IgG
- Reactivity:Mouse
- Cross adsorption:No
- Form:liquid
- Gene ID:P09793
- Antigen synonyms:Ctla4
- Storage buffer:Phosphate-buffered aqueous solution, ≤0,09% Sodium azide, may contain carrier protein/stabiliser, ph 7,2.
- Storage temperature:The product should be stored undiluted at 4 °C. Do not freeze.
- Shipping temperature:4 °C
- Purification:The monoclonal antibody was purified utilizing affinity chromatography.
- Pk:0,1 mg
Specifications
About this item
The UC10-4F10-11 monoclonal antibody specifically reacts with the mouse Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4), also known as CD152. It is a protein with a structure similar to CD28 regarding the genomic organization, amino acid sequence, and structure. CTLA-4 is expressed on activated T cells and CD25+/CD4+ Treg lymphocytes and binds the members of the B7 family, B7-1 (CD80) and B7-2 (CD86), with higher affinity than CD28. CD28 seems to provide opposing signal to T lymphocytes, while CD152 inhibits the T lymphocytes progression to an activated state and their proliferation, CD28 is a costimulator. The mouse UC10 -4F10-11 monoclonal antibody does not cross-react with the rat leukocytes.
Type: Primary
Antigen: Ctla4
Clonality: Monoclonal
Clone: UC10-4F10-11
Conjugation: Unconjugated
Epitope:
Host: Hamster
Isotype: IgG
Reactivity: Mouse