Specifications
- Antibody type:Primary
- Antigen name:RNF12
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 680
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Western blot:Yes
- Epitope:525-624/624
- Form:Liquid
- Gene ID:51132
- Antigen synonyms:Renal carcinoma antigen NY-REN-43|RLIM|RNF12|RING finger protein 12|NY-REN-43|RING finger LIM domain-binding protein|R-LIM|LIM domain-interacting RING finger protein|E3 ubiquitin-protein ligase RLIM
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:69 kDa
- Storage temperature:Store at ‒20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human RNF12
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimise sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.
Type: Primary
Antigen: RNF12
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 525-624/624
Host: Rabbit
Isotype: IgG
Reactivity: Human; Mouse; Rat