- Druh protilátky:Primární
- Název antigenu:GPS1 Ser474
- Klonovalita:Polyclonal
- Spojení:Alexa Fluor® 680
- Hostitel:Rabbit
- Imunochemie:Yes
- ImunoFluorescence:Yes
- Izotyp:IgG
- Reaktivita:Human,Rat,Mouse
- Western blot:Yes
- Formulář:Liquid
- Identifikační číslo genu:2873
- Synonyma antigenu:COPS1|GPS1|Signalosome subunit 1|CSN 1|Protein GPS1|p-GPS1Ser474|Y59A8A.1|GPS-1|GPS1S474|constitutive photomorphogenic homolog subunit 1|CSN1_HUMAN|JAB1-containing signalosome subunit 1|SGN1|G protein pathway suppressor 1|COP9 signalosome complex subunit 1|CSN1 phospho S474|Arabidopsis Fus6/Cop 11 homolog|COP9|MFH protein|Protein MFH
- Modifikace:Phosphorylation (Ser474)
- Skladovací pufr:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Skladovací teplota:Store at ‒20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Koncentrace:1 µg/µl
- Transportní teplota:4 °C
- Imunogen:KLH conjugated synthetic phosphopeptide derived from human GPS1 around the phosphorylation site of Ser474
- Čištění:Purified by Protein A
- Typ balení:Vial
- Bal.:100 µl
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein-and mitogen-activated protein kinase-mediated signal transduction.
Type: Primary
Antigen: GPS1 Ser474
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range:
Host: Rabbit
Isotype: IgG
Reactivity: Human; Mouse; Rat