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Anti-COPS4 Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Catalog # BOSSBS-9123R-A750
Supplier:  Bioss
Anti-COPS4 Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Catalog # BOSSBS-9123R-A750
Supplier:  Bioss

Specifications

  • Antibody type:
    Primary
  • Antigen name:
    COPS4
  • Clonality:
    Polyclonal
  • Conjugation:
    Alexa Fluor® 750
  • Host:
    Rabbit
  • ImmunoChemistry:
    Yes
  • ImmunoFluorescence:
    Yes
  • Isotype:
    IgG
  • Reactivity:
    Human,
    Rat,
    Mouse
  • Western blot:
    Yes
  • Epitope:
    101-220/406
  • Form:
    Liquid
  • Gene ID:
    51138
  • Antigen synonyms:
    COP9 signalosome complex subunit 4|COP9 signalosome subunit 4|COP9 constitutive photomorphogenic homolog subunit 4|CSN4_HUMAN|MGC94896|COP9 complex S4|JAB1 containing signalosome subunit 4|COP9 complex homolog subunit 4|SGN4|DCH4|CSN4 SCHPO|CSN4|Signalosome subunit 4|JAB1-containing signalosome subunit 4|CSN complex subunit 4|COPS4|CH4
  • Modification:
    Unmodified
  • Storage buffer:
    Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
  • Storage temperature:
    Store at ‒20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
  • Concentration:
    1 µg/µl
  • Shipping temperature:
    4 °C
  • Immunogen:
    KLH conjugated synthetic peptide derived from human COPS4
  • Purification:
    Purified by Protein A
  • Pack type:
    Vial
  • Pk:
    100 µl

Specifications

About this item

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Type: Primary
Antigen: COPS4
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 101-220/406
Host: Rabbit
Isotype: IgG
Reactivity: Human; Mouse; Rat