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Anti-Sumo 2+3 Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Anti-Sumo 2+3 Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Catalog # BOSSBS-7338R-A750
Supplier:  Bioss
Anti-Sumo 2+3 Rabbit Polyclonal Antibody (Alexa Fluor® 750)
Catalog # BOSSBS-7338R-A750
Supplier:  Bioss

Specifications

  • Antibody type:
    Primary
  • Antigen name:
    Sumo 2+3
  • Clonality:
    Polyclonal
  • Conjugation:
    Alexa Fluor® 750
  • Flow cytometry:
    Yes
  • Host:
    Rabbit
  • ImmunoChemistry:
    Yes
  • ImmunoFluorescence:
    Yes
  • Isotype:
    IgG
  • Reactivity:
    Human
  • Western blot:
    Yes
  • Epitope:
    21-95/95
  • Form:
    Liquid
  • Antigen synonyms:
    Suppressor of m two 3 homolog 2|SMT3 A|Suppressor of m two 3 homolog 3|SMT3 B|OTTHUMP00000115275|SMT3 suppressor of m two 3 homolog 2 S. cerevisiae|Small ubiquitin like modier protein 3|SUMO3_HUMAN|SMT3 homolog 1|Sumo3|Small ubiquitin related modier 3|Sumo2|SMT3 H1|SMT3H1|OTTHUMP00000115276|HSMT3|SMT3 homolog 2|SUMO2_HUMAN|MGC117191|Ubiquitin like protein SMT3B|Small ubiquitin related modier 2|OTTHUMP00000115277|Sumo 2|Sentrin 2|SMT3 homolog|SMT3 suppressor of m two 3 homolog 3|SMT3 H2|Sumo 3|SMT3B|SMT3A|SMT3 suppressor of m two 3 homolog 1|Ubiquitin like protein SMT3A|SMT3 suppressor of m two 3 homolog 3 S. cerevisiae|SMT3 suppressor of m two 3 homolog 2|SMT3H2|Small ubiquitin like modier 2
  • Modification:
    Unmodified
  • Storage buffer:
    Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
  • Molecular weight:
    10,9 and 10,5 kDa
  • Storage temperature:
    Store at ‒20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
  • Concentration:
    1 µg/µl
  • Shipping temperature:
    4 °C
  • Immunogen:
    KLH conjugated synthetic peptide derived from human Sumo 2+3
  • Tested applications:
    ICC
  • Purification:
    Purified by Protein A
  • Pack type:
    Vial
  • Pk:
    100 µl

Specifications

About this item

The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2 and SUMO-3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesised as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilise the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, SUMO-2 and SUMO-3 proteins localise to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilises Ubc9 for conjugation to several target proteins, which include IkBa, MDM2, p53, PML and Ran GAP1. SUMO-2 and SUMO-3 contribute to a greater percentage of protein modification than does SUMO-1, and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates b-Amyloid generation and may be critical in the onset or progression of Alzheimer?s disease.

Type: Primary
Antigen: Sumo 2+3
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 21-95/95
Host: Rabbit
Isotype: IgG
Reactivity: Human