- Antibody type:Primary
- Antigen name:Tau protein Ser199
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 750
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Rat,Mouse
- Western blot:Yes
- Environmentally Preferable:
- Form:Liquid
- Gene ID:4137
- Antigen synonyms:MGC138549|FTDP 17|Microtubule associated protein tau isoform 4|MAPT|AI413597|TAU_HUMAN|MGC134287|FLJ31424|PPND|Mtapt|FTDP17|MAPTL|G protein beta1/gamma2 subunit interacting factor 1|Disinhibition dementia parkinsonism amyotrophy complex|MTBT1|Tauopathy and respiratory failure, included|MTBT2|Microtuble-associted protein Tau|MGC156663|PHF tau|AW045860|Neurofibrillary tangle protein|RNPTAU|pTau|Paired helical filament tau|MAPTphospho S199|PHF-tau|G Protein beta 1 gamma 2 subunit interacting factor 1|MSTD|DDPAC
- Modification:Phosphorylation (Ser199)
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:52/79 kDa
- Storage temperature:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic phosphopeptide derived from human MAPT isoform 2 around the phosphorylation site of Ser199 [YS(P-S)PG]
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Tau proteins are important Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilisation. Tau proteins subcellular located in the axons of neurons, in the cytoso l and in association with plasma membrane components. It expressed in neurons. PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
Type: Primary
Antigen: Tau protein Ser199
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range:
Host: Rabbit
Isotype: IgG
Reactivity: Mouse; Rat; Others