Specifications
- Antibody type:Primary
- Antigen name:UCMA
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 680
- Host:Rabbit
- Isotype:IgG
- Western blot:Yes
- Epitope:21-120/138
- Form:Liquid
- Gene ID:221044
- Antigen synonyms:Grp|Gla-rich protein|Ucma-C|GRP|Unique cartilage matrix-associated protein C-terminal fragment|UCMA_HUMAN|OTTMUSP00000011599|Unique cartilage matrix associated protein|UCMA|Gla rich protein|RP23-272I15,1|C10orf49|Upper zone of growth plate and cartilage matrix associated
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:14 kDa
- Storage temperature:Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human UCMA
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
UCMA is a 138 amino acid secreted protein that is highly expressed in resting chrondrocytes in developing long bones and is thought to function in the early phase of chrondrocyte differentiation. A furin-like protease processes UCMA into an N-terminal 37 amino acid peptide and a C-terminal 74 amino acid peptide, which is referred to as Unique cartilage matrix-associated protein C-terminal fragment (Ucma-C). Introduction of recombinant Ucma-C interferes with osteogenic differentiation of mesenchymal stem cells, MC3T3-E1 preosteoblasts and primary osteoblasts. This suggests that Ucma may be involved in the negative regulation of osteogenic differentiation of osteochondrogenic precursor cells at the cartilage-bone interface and in peripheral zones of fetal cartilage.
Type: Primary
Antigen: UCMA
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 21-120/138
Host: Rabbit
Isotype: IgG
Reactivity: