Anti-p27/Kip1 Mouse Monoclonal Antibody [clone: SPM348]
Catalog # NOVUNBP2-32890-0.1
Supplier: Novus Biologicals
Specifications
- Antigen name:Cyclin-dependent kinase inhibitor p27
- Antigen symbol:P27/KIP
- Clonality:Monoclonal
- Clone:SPM348
- Conjugation:Unconjugated
- Host:Mouse
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG1 kappa
- Reactivity:Primates,Human,Rat,Mouse
- Antigen synonyms:CDKN1B|CDKN4
- UniProtKB:P46527
- Storage buffer:10 mM PBS with 0.05% BSA; Preservative:
0.05% Sodium Azide - Storage temperature:Store at 4 °C
- Concentration:0.2 mg/ml
- Immunogen:Purified GST-p27 fusion protein of Mouse origin
- Purification:Protein A or G purified
- Pk:0,1 mg
Specifications
About this item
p27(Kip1) is a cyclin-dependent kinase inhibitor involved in G1 arrest. p27(Kip1) binds to and inhibits cyclinE-Cdk2 complex, cyclinA-CDK2 and cyclinD1-CDK4 (1). p27(Kip1) is regulated by phosphorylation on serine 10 (S10) and threonine 187 (T187). Phosphorylation by CDK2 on T187 results in ubiquitylation and degradation of p27(Kip1) (2); while phosphorylation by hKIS on S10 signals the nuclear export to the cytoplasm (3).