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Anti-p27/Kip1 Mouse Monoclonal Antibody [clone: SPM348]
Catalog # NOVUNBP2-32890-0.1
Supplier:  Novus Biologicals
Anti-p27/Kip1 Mouse Monoclonal Antibody [clone: SPM348]
Catalog # NOVUNBP2-32890-0.1
Supplier:  Novus Biologicals

Specifications

  • Antigen name:
    Cyclin-dependent kinase inhibitor p27
  • Antigen symbol:
    P27/KIP
  • Clonality:
    Monoclonal
  • Clone:
    SPM348
  • Conjugation:
    Unconjugated
  • Host:
    Mouse
  • ImmunoChemistry:
    Yes
  • ImmunoFluorescence:
    Yes
  • Isotype:
    IgG1 kappa
  • Reactivity:
    Primates,
    Human,
    Rat,
    Mouse
  • Antigen synonyms:
    CDKN1B|CDKN4
  • UniProtKB:
    P46527
  • Storage buffer:
    10 mM PBS with 0.05% BSA; Preservative:
    0.05% Sodium Azide
  • Storage temperature:
    Store at 4 °C
  • Concentration:
    0.2 mg/ml
  • Immunogen:
    Purified GST-p27 fusion protein of Mouse origin
  • Purification:
    Protein A or G purified
  • Pk:
    0,1 mg

Specifications

About this item

p27(Kip1) is a cyclin-dependent kinase inhibitor involved in G1 arrest. p27(Kip1) binds to and inhibits cyclinE-Cdk2 complex, cyclinA-CDK2 and cyclinD1-CDK4 (1). p27(Kip1) is regulated by phosphorylation on serine 10 (S10) and threonine 187 (T187). Phosphorylation by CDK2 on T187 results in ubiquitylation and degradation of p27(Kip1) (2); while phosphorylation by hKIS on S10 signals the nuclear export to the cytoplasm (3).