Sartoclear Dynamics® Lab products are filtration kits designed for the clarification and sterile filtration of up to 1000 ml of mammalian cell cultures.

• Ready to use
• Fast and effortless
• Clarification technology available for laboratories but also for process volumes

Sartoclear Dynamics® Lab kits enable clarification and sterile filtration to be performed in a single step. These kits simplify the process by fully eliminating the centrifugation step otherwise needed for clarification. As a result, they enable harvested cell cultures to be efficiently clarified and sterilised in minutes.

These kits combine pouches of filter aid for clarification and vacuum filtration units for sterile filtration. The filter aid facilitates filtration through the sterile filter while allowing complete protein recovery. The pouches are filled with pre-wetted, highly pure diatomaceous earth (DE), an optimised grade for cell culture harvests, which is inert and insoluble.

Sartoclear Dynamics® Lab products are available either with a 0,22 or 0,45 µm polyethersulfone membrane. Both membranes provide fastest flow rates due to their asymmetric structure and ensure lowest protein binding as well as extractable. Therefore, they are the membranes of choice for cell culture harvesting applications.

Clarification and sterile filtration are performed in a single step:
1. Attach the Sartolab® RF unit to a vacuum source. Pour the filter aid into your cell culture.
2. Mix to homogenise. Pour the cell culture and filter aid mixture into the Sartolab® RF first.
3. Then filter by simply using the pump.
4. After 5 to 15 minutes, the sample will be available for subsequent downstream processing steps, such as protein purification and concentration.