Mouse recombinant IL36 alpha (from E. coli)
PRSI90-282
:
- Pk:10 µG
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Mouse
- Tag sequence:Tag Free
- Storage conditions:Stable for at least 6 months after receipt when stored at −20 °C.
- Biological activity:Induces secretion of IL-6 in BMDCs at a concentration of 100ng - 1ug/ml.
- Protein synonyms:Interleukin-1 Family Member 6|Interleukin-36alpha|IL-1H1|Interleukin-1epsilon|FIL1epsilon|IL-1F6|Interleukin-1 Homolog 1
- Protein/peptide name:IL36 alpha
- Purity:>95% (SDS-PAGE)
- Sequence:Arg8-His160
- Formulation:Lyophilized, Contains PBS.
IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.
Fusion-Tag: Tag Free
This recombinant proteins is for research use only.