Specifications
- Antigen name:Lysosomal-associated membrane protein 2
- Antigen symbol:LAMP2
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human,Mouse
- Western blot:Yes
- Antigen synonyms:LAMP-2|LGP-B|Lysosome-associated membrane protein 2|CD107 antigen-like family member B|LAMP2|Lysosome-associated membrane glycoprotein 2|CD107b|Lysosomal membrane glycoprotein type B
- Storage buffer:PBS containing 0.02% sodium azide
- Immunogen:LAMP-2 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus ofhuman LAMP-2.
- Tested applications:E, WB, ICC
- Purification:Affinity chromatography purified via peptide column
- Size:100 µg
- Pk:100 µG
Specifications
About this item
LAMP-2 Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components and is negatively regulated by TOR (Target of rapamycin). LAMP-2, a highly glycosylated protein associated with the lysosome, has recently been shown to be important in autophagy as mice deficient in this protein failed to convert autophagic vacuoles into vacuoles leading to impaired degradation of long-lived proteins. This correlates with the finding that human LAMP-2 deficiency causing Danon's disease is associated with the accumulation of autophagic material in striated myocytes. LAMP-2 exists in multiple isoforms.
Type:
Antigen: LAMP2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse