- Druh protilátky:Primární
- Název antigenu:Casein beta
- Symbol antigenu:CASB
- Klonovalita:Polyclonal
- Spojení:HRP (Horseradish Peroxidase)
- Hostitel:Rabbit
- Imunochemie:Yes
- Izotyp:IgG
- Reaktivita:Human,Rat,Mouse
- Western blot:Yes
- Křížová adsorbce:No
- Formulář:liquid
- Identifikační číslo genu:1447
- Synonyma antigenu:ALIEN|COP9 signalosome complex subunit 2|thyroid receptor interacting protein 15|SGN2|subunit 2|CSN2|COP9 constitutive photomorphogenic homolog subunit 2|JAB1-containing signalosome subunit 2|COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)|COP9|COPS2|TRIP15
- Skladovací pufr:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% Gentamicin. Store at 4°C for 12 months.
- Skladovací teplota:Store at –20 °C for 12 months
- Koncentrace:1 μg/μl
- Transportní teplota:4°C
- Čištění:Purified by Protein A
- Bal.:100 µl
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
Recommended Dilutions: Western Blot: 1:100-1000; IHC-P: 1:100-500
Type: Primary
Antigen: CSN2
Clonality: Polyclonal
Clone:
Conjugation: HRP (Horseradish Peroxidase)
Epitope:
Host: Rabbit
Isotype:
Reactivity: