- Antibody type:Primary
- Antigen name:Breast Cancer type 1 susceptibility protein
- Antigen symbol:BRCA1
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 488
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human
- Cross adsorption:No
- Form:liquid
- Gene ID:672
- Antigen synonyms:BROVCA1|BRCA1/BRCA2-containing complex|subunit 1|PPP1R53|breast and ovarian cancer sususceptibility protein 1|RING finger protein 53|IRIS|protein phosphatase 1|breast cancer type 1 susceptibility protein|RNF53|PNCA4|regulatory subunit 53|breast and ovarian cancer susceptibility protein 1|PSCP|BRCAI|BRCC1
- Modification:phospho-Ser1189
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Purification:Purified by Protein A
- Pk:100 µl
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009].
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: BRCA1
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 488
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human