Specifications
- Druh protilátky:Primární
- Název antigenu:Protein Kinase, AMP-activated Non-catalytic Subunit Beta
- Symbol antigenu:PRKAB1
- Klonovalita:Polyclonal
- Spojení:Cy5®
- Hostitel:Rabbit
- Imunochemie:Yes
- Izotyp:IgG
- Reaktivita:Rat,Mouse
- Křížová adsorbce:No
- Formulář:liquid
- Identifikační číslo genu:19079
- Synonyma antigenu:kinase AMPK-beta1|AMPK-beta1|AMPK beta-1 chain|5'-AMP-activated protein kinase beta-1 subunit|PRKAB1|AAKB1
- Modifikace:phospho-Ser108
- Skladovací pufr:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Skladovací teplota:Store at 4°C for 12 months
- Koncentrace:1 μg/μl
- Transportní teplota:4°C
- Čištění:Purified by Protein A
- Bal.:100 µl
Specifications
About this item
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008].
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: PRKAB1
Clonality: Polyclonal
Clone:
Conjugation: Cy5®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Mouse, Rat