The matrix metalloproteinase (MMP) RED and GREEN Drug Discovery Kits are complete assay systems designed to screen MMP inhibitors, using long-wavelength quenched fluorogenic substrates OmniMMP™ RED or Fluorogenic Substrate (GREEN). The assays are performed in a convenient 96-well microplate format, with the compound NNGH also included as a prototypic control inhibitor.

• Improved red-shifted substrate with better kinetics and brighter signal
• Includes active recombinant enzyme, substrate, and assay buffer
• Convenient real-time kinetics of cleavage is easily determined
• Microplate format for high-throughput screening

Proteins of the matrix metalloproproteinase (MMP) family are collectively involved in the breakdown of extracellular matrix proteins and processing of bioactive molecules and are required for some normal processes. Unfortunately, these proteins are also associated with many pathological processes including cirrhosis, arthritis, metastasis, and chronic cardiovascular diseases. Collagenases (MMP-1, MMP-8, and MMP-13) and gelatinases (MMP-2 and MMP-9) also break down skin collagens, contributing to aging and wrinkling.