You searched for: Proteins and Peptides

Proteins are used in routine laboratory procedures such as binding enzymes or coupling peptides to carrier proteins. These kits, mixture solutions, and collagen matrices fulfill a myriad of essential laboratory functions for developing relationships between proteins and other cellular components. The stimulating proteins offered have various amino acid arrangements and functions to fulfill any sample manipulation for testing purposes in any field.

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VWR®, Bovine serum albumin (BSA)

Supplier: VWR Chemicals

Produced by a heat shock process using sodium caprylate as a stabiliser with additional treatments including dialysis and deionisation.

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Human Recombinant NAP-2 (from E. coli)

Supplier: Shenandoah Biotechnology

Neutrophil activating peptide 2 (NAP-2), also known as CXCL7, is a member of the CXC family of chemokines. NAP-2 is a carboxyl-terminal fragment produced by proteolytic cleavage of the platelet basic protein (PBP). NAP-2 is released from platelets and binds to the receptors CXCR1 and CXCR2 to chemoattract and activate neutrophils during inflammatory events.

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Anabaenopeptin A (from Microcystis aeruginosa)

Supplier: Enzo Life Sciences

Anabaenopeptins are a highly diverse group of bioactive peptides produced by several genera of cyanobacteria such as Anabaena, Planktothrix, Microcystis and Nodularia. These peptides are commonly detected in cyanobacterial blooms along with the well known microcystins. Unique cyclic peptides where lysine is conserved in position 2 and cyclisation is achieved by linkage of the lysine to the C-terminal amino acid. In addition the side chain of a single amino acid is attached via a ureido bond. Bioactive peptides originally isolated from Anabaena flos-aquae NRC 525-17 where they were shown to be non-toxic in mice but had dose dependant relaxations in rat aortic preparations with endothelium precontracted with 0.1µM norpinephrine.
Anabaenopeptins inhibit protein phosphatase.

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VWR®, Gelatin

Supplier: VWR Chemicals

VWR®, Gelatin

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MG-132

Supplier: Enzo Life Sciences

MG-132 is a potent, cell permeable and selective proteasome inhibitor (Ki = 4 nM).1 It inhibits NF-κB activation by preventing IκB degradation (IC50 = 3 μM). The peptide blocks degradation of short-lived proteins, which in turn induces HSP and ER chaperone expression, leading to thermotolerance (1 μM MG-132, 2 h.). It also stimulates neurite outgrowth in PC12 cells (20 nM optimal). The peptide has also been reported to increase the survival rate of mesenchymal stem cells following their transplantation. IC50’s for inhibition of Suc-LLVY-AMC and Z-LLL-AMC cleaving activities of proteasome were 0,85 and 0,1 μM respectively. The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems, thus blockade of UPS by MG-132 activates autophagy.

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Caveolin-1 scaffolding domain peptide

Supplier: Enzo Life Sciences

Cell permeable peptide that blocks eNOS (NOS III) activity and cellular nitric oxide (NO) release in vitro and reduces inflammation and tumorigenesis in vivo. Caveolin-1 interacts with several lipid-modified signalling ligands, such as EGFR, eNOS, G-protein α-subunits, PKCα, H-Ras, and Src, via the C1-SD82-101 sequence.