Anti-ARFGEF2 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Catalog # BOSSBS-11804R-A647

Supplier: Bioss

Catalog # BOSSBS-11804R-A647

Supplier: Bioss

Specifications

Antibody type:
Primary
Antigen name:
ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 2
Antigen symbol:
ARFGEF2
Clonality:
Polyclonal
Conjugation:
Alexa Fluor® 647
Host:
Rabbit
ImmunoChemistry:
Yes
Isotype:
IgG
Reactivity:
Human,
Rat,
Mouse
Environmentally Preferable:
Cross adsorption:
No
Form:
liquid
Antigen synonyms:
Brefeldin A inhibited GEP 2|BIG2|ARFGEP2|BIG 2|ARFGEF 2|Brefeldin A inhibited guanine nucleotide exchange protein 2|ADP ribosylation factor guanine nucleotide exchange factor 2|Brefeldin A inhibited 2|ARFGEF2|dJ1164I10.1|ADP ribosylation factor guanine nucleotide exchange factor 2 brefeldin A inhibited|BIG2_HUMAN.
Storage buffer:
Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Storage temperature:
Store at 4°C for 12 months
Concentration:
1 μg/μl
Shipping temperature:
4°C
Purification:
Purified by Protein A
Pk:
100 µl

Specifications

About this item

Guanine nucleotide-exchange proteins (GEPs) accelerate replacement of bound GDP with GTP and thereby activate ADP-ribosylation factors (ARFs), a family of guanine nucleotide-binding proteins that play an important role in intracellular vesicular trafficking. GEPs comprise two major families, large GEPs that are inhibited by brefeldin A (BFA), a protein that effects golgi structure, and a group of smaller GEPs that are insenstive to BFA. Two genes for GEPs found on human chromosomes 8 and 20 encode BFA sensitive GEPs designated BIG1 and BIG2. Both GEPS contain a sec7 domain that is responsible for their brefeldin inhibition and also their catalytic activity. In vivo, BIG1 and BIG2 exist in macromolecular complexes that move between the golgi membranes and cytosol. BIG2 associates with PKA regulatory subunits, implying that BIG2 may act as an A kinase-anchoring protein (AKAP) that could coordinate the cAMP and ARF regulatory pathways.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: ARFGEF2
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 647
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat