5269 Results for: "Enzo Life Sciences"

Supplier: Enzo Life Sciences

SCREEN-WELL® bioactive lipid library contains 190 bioactive lipids in a 96 well format. Ideal for screening or identifiying recombinant orphan G protein-coupled receptors, target validation, secondary screening, validating new assays and for routine pharmacological applications.

Supplier: Enzo Life Sciences

For the quantitative determination of soluble human HLA-G (leukocyte antigen-G) in plasma, serum, cell culture supernatant and other body fluids. Cross-reacts strongly with bovine, dog, goat, monkey, rabbit and sheep HLA-G. Cross-reacts weakly with cat HLA-G.

Supplier: Enzo Life Sciences

The Protein carbonyl ELISA kit is an antibody-based detection set. It has higher sensitivity, lower background, is less labour-intensive and handles more samples per day as compared to colorimetric assays.

Supplier: Enzo Life Sciences

The kit offers a set of six different MAbs specific for serine phosphorylation sites. Phosphorylation patterns in a given cell extract may differ when probed with different antibodies due to sequence specificity. Recognition therefore depends on two criteria: phosphorylation and surrounding aa motif. If one of the two criteria is not fulfilled, the antibody will not detect the phosphorylation site. Specificity has been determined by epitope mapping using degenerated phosphopeptide libraries. Clone 16B4 strongly interacts with pSK and pSP motifs, thus specifically recognizes substrates of MAP/SAP Kinases and CDC kinases.Clones 1C8, 4A3, 4A9, 4H4 and 7F12 interact with epitopes containing phosphoserine in the context of positive or neutral aa (e.g. substrates of PKA, PKB, PKC, PKG etc.) Though revealing a similar pattern in epitope mapping using phosphopeptide libraries, these antibodies interact with different sets of phosphoproteins in whole cell lysates.

Supplier: Enzo Life Sciences

Synthetic peptides that irreversibly inhibit the activity of each of the caspase-family proteases. YVAD is the recognition sequence for caspase-1/ICE, DEVD is the recognition sequence for caspase-3/CPP32, VEID is the recognition sequence for caspase-6/Mch2, IETD is the recognition sequence for caspase-8/ FLICE, and VAD is the recognition sequence for a caspase(s) that functions upstream of most other caspases.   

Supplier: Enzo Life Sciences

For the detection of Cytochrome c translocation from mitochondria into cytosol during apoptosis.

Supplier: Enzo Life Sciences

A QuantiZyme™ Assay System. The MMP-10 Fluorometric (also known as fluorimetric) Drug Discovery Kit is a complete assay sytem designed to screen for inhibitors of matrix metalloproteinase-10 (MMP-10, stromelysin-2) using a quenched fluorogenic peptide: OmniMMP™ fluorogenic substrate Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH. Mca fluorescence is quenched by the Dpa group until cleavage by MMPs at the Gly-Leu bond separates the two moieties.

Supplier: Enzo Life Sciences

A QuantiZyme™ Assay System. The MMP-2 Colorimetric Drug Discovery Kit is a complete assay system designed to screen inhibitors of matrix metalloproteinase-2 (MMP-2, gelatinase A) using a thiopeptide as a chromogenic substrate. The assays are performed in a convenient 96-well microplate format. The kit is useful to screen inhibitors of MMP-2, a potential therapeutic target.

Supplier: Enzo Life Sciences

The Screen-Well® epigenetics library contains 43 compounds with defined activity against enzymes which carry out epigenetic modification of lysine. It also includes DNA methylation inhibitors. Compounds are dissolved in DMSO at 10 mM and aliquoted into deep-well plates at 100 µl or 500 µl per well. The library is a useful tool for chemical genomics, assay development and other pharmacological applications. The library contains inhibitors of these important enzymes: HDACs, SIRTs, Lysine demethylases, HATs, Histone methyl transferases, DNA methyltransferases as well as SIRT activators. A variety of structurally and mechanistically different compound classes are included.

Supplier: Enzo Life Sciences

Antibiotic. Inhibits protein synthesis (elongation) by interfering with peptidyl tRNA translocation. Effective against Gram-negative and Gram-positive bacteria (Gonnococcus only). Mutation in rpsE (the gene for ribosomal protein S5) prevents binding of spectinomycin.

Supplier: Enzo Life Sciences

Mixture of alamethicin homologs. Membrane permeabilizing antibiotic. Applications include increasing [32P] incorporation into phosphatidylinositol 4-phosphate and permeabilization of sarcoplasmic reticulum vesicles. Causes fusion of lipid vesicles.

Supplier: Enzo Life Sciences

SCREEN-WELL® ICCB Known Bioactives Library is a collection of 472 diverse biologically active compounds with defined biological activity and was developed in collaboration with the Harvard Institute of Chemistry and Cell Biology.

Supplier: Enzo Life Sciences

Anti-tumor agent. Induces apoptosis via DNA damage. Radiomimetic DNA-cleaving agent that produces double and single DNA strand breaks through an oxygen-radical-dependent mechanism. Inhibits intracellular DNA replication. DNA alkylating agent.

Supplier: Enzo Life Sciences

CDK inhibitor

Supplier: Enzo Life Sciences

A potent and selective TRPA1 inhibitor.

Supplier: Enzo Life Sciences

Ca²⁺ channel blocker.

Supplier: Enzo Life Sciences

TRPV1 antagonist.

Supplier: Enzo Life Sciences

A potent irreversible inactivator of calmodulin. Possesses potent antiproliferative and cytotoxic activity. It is also an irreversible D2 dopamine receptor antagonist.

Supplier: Enzo Life Sciences

Produced in E. coli. Non-glycosylated protein, containing 135 amino acids.

Supplier: Enzo Life Sciences

Synthetic peptide corresponding to aa 345-369 of human, mouse or rat adiponectin receptor 1 (AdipoR1).

Supplier: Enzo Life Sciences

Angiotensin I

Supplier: Enzo Life Sciences

Dog;Human;Pig Endothelin 2

Supplier: Enzo Life Sciences

Endogenous GHS-R ligand

Supplier: Enzo Life Sciences

Transferrin is a serum glycoprotein involved in iron transport. Transferrin exists in two forms, the iron-free Apotransferrin, which binds two Fe3+ ions to generate Ferrotransferrin. Apotransferrin remains tightly bound to its receptor until the complex is recycled to the cell surface, where Apotransferrin is released into the extracellular space to recruit more Fe3+ ions.

Supplier: Enzo Life Sciences

beta-Amyloid (25-35)

Supplier: Enzo Life Sciences

Synapsin I, II and III belong to a family of neuron-specific phosphoproteins which maintain a reserve pool of vesicles in the vicinity of the active zone by tethering synaptic vesicles to each other and to an Actin-based cytoskeleton meshwork. They have been shown to regulate neurotransmitter release in mature synapses and to accelerate development of the nervous system.

Supplier: Enzo Life Sciences

Syntaxins are type II integral membrane proteins localized to membranes that regulate vesicle transport, protein maturation, and exocytosis. Syntaxin 1A resides in the nerve terminals of sensory neurons and nerve fibers reaching small blood vessels. Syntaxin 2 localizes to the apical plasma membrane and regulates epithelial-mesenchymal interactions. Syntaxin 6 is primarily localized to the trans-Golgi network, and partially co-localizes with AP-1 on clathrin-coated membranes. Syntaxin 13 is ubiquitously expressed and localizes to the tubular early and recycling endosomes, as well as endosomal vacuoles.

Supplier: Enzo Life Sciences

NOS inhibitor

Supplier: Enzo Life Sciences

Produced in E. coli.

Supplier: Enzo Life Sciences

Isolated from human rheumatoid synovial fibroblasts. Requires activation.