5268 výsledků pro: "ENZO LIFE SCIENCES"

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Immunosuppressant.

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F-ATPase inhibitor.

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Phomopsin A ≥98% (by HPLC)

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Triterpenoid. Antitumor agent. Induces caspase-dependent apoptosis by inhibiting the chymotrypsin-like activity of the proteasome. Inhibits NF-κB activation via inhibition of IKKα or IKKβ. Inhibits induction of inducible nitric oxide synthase (iNOS; NOS II). Shows in vitro antimalarial and insecticidal activity. Induces mitochondrial cell death. Has antiproliferative, antifungal and antiviral properties. Potent and reversible monoacylglycerol lipase (MGL) inhibitor.

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PKC activator.

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Protein synthesis inhibitor

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Antitumor antibiotic. Catalytic inhibitor of topoisomerase II. Strong protein phosphatase 2A (PP2A) inhibitor (IC50=3.2nM). Weak inhibitor for PP1 (IC50=131µM). No apparent effect on PP2B. The binding site for fostriecin on PP2A is different from that of okadaic acid.

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Co-metabolite of nemadectin. Antitumor agent with weak antifungal and nematocidal activity.

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Inhibitor of protein kinase C (PKC) and cyclin-dependent kinases (CDKs) resulting in accumulation of cells in the G1 phase and induction of apoptosis. Enhances the cytotoxicity of other anticancer drugs, such as DNA-damaging agents and anti-metabolite drugs, through putative abrogation of G2 and/or S phase accumulation induced by these agents.

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PARP-1 inhibitor

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Cell cycle inhibitor

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Fluoroquinolone antibacterial agent. Inhibits bacterial DNA gyrase (topoisomerase). Effective against Gram-positive and Gram-negative aerobic bacteria, anaerobic bacteria and Chlamydia trachomatis.

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Antibiotic. Inhibits growth of prokaryotic and eukaryotic microorganisms and mammalian cells. Inhibits protein synthesis at the translocation step on the 70S ribosome and causes misreading of the mRNA. Penetrates cells that have been permeabilized by virus infection, hence it can act as an effective antiviral agent.

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Produced in HEK 293 cells. The extracellular domain of human CD137L (aa 49-254) is fused at the N-terminus to a linker peptide (10 aa) and a FLAG®-tag.

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Produced in CHO cells. Human LRRC32 (aa 20-627) is fused to the Fc portion of human IgG1.

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Produced in HEK 293 cells. The extracellular domain of human CD40L (CD154) (aa 116-261) is fused at the N-terminus to the Fc portion of human IgG1 and a linker peptide (20 aa).

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Produced in HEK 293 cells. The extracellular domain of human LIGHT (aa 89-240) is fused at the N-terminus to a linker peptide (10 aa) and a FLAG®-tag.

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Produced in E. coli. Dimer of two identical subunits (119 aa) linked together by very strong hydrophobic interactions.

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Produced in HEK 293 cells. The extracellular domain of human Fas (CD95; APO-1) (aa 7-154) is fused to the Fc portion of human IgG1.

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Topoisomerase II inhibitor

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Nitric oxide (NO) donor.

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Nitric oxide (NO) donor.

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Heme oxygenase activator.

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Nitric oxide (NO) donor.

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Macrotetrolide antibiotic. Monovalent cation ionophore with high selectivity for ammonium and potassium. Specifically inhibits the processing of cytoplasmic precursor proteins destined for the mitochondria. Inhibits the effects on P170 glycoprotein-mediated efflux of chemotherapeutic agents in multidrug resistant (MDR) cancer cells.

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Ionomycin calcium salt

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Cytotoxic in various cell lines. Induces apoptosis via elevation of peroxide and superoxide radical levels. Affects gap-junctional intercellular communication by mediation of tyrosine phosphorylation.Inhibitor of indoleamine 2,3-dioxygenase (IDO) with an IC50 of ~1µM.

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Activator of PKG and CNG channels.

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D(+)-Biotin

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AMPA/kainate receptor antagonist