Supplier: Cayman Chemical

Anti-PCSK9 Rabbit Polyclonal Antibody

Supplier: Cayman Chemical

Purvalanol A is a potent, cell-permeable, and selective inhibitor of cyclin-dependent kinases (CDKs) with IC50 values of 4, 70, 35, 850, and 75 nM for cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively.

Supplier: Cayman Chemical

Probenecid

Supplier: Cayman Chemical

18β-Glycyrrhetinic acid is an inhibitor of the complement pathway (IC₅₀ = 35 μM). At 100 mg/kg/day, 18β-glycyrrhetinic acid is protective against diabetes complications by reducing lipid peroxidation and increasing antioxidant activity in diabetic rats. It inhibits mammalian DNA polymerases α, γ, κ and λ with IC₅₀ values of 16,1, 19,3, 15,8 and 13,7 μM, respectively. At 100-200 μM, 18β-glycyrrhetinic acid suppresses LPS-induced TNF-α production and NF-κB activation in mouse macrophages.

Supplier: Cayman Chemical

Dihydroethidium is a cell-permeable blue fluorescent dye that upon entering cells interacts with superoxide to form oxyethidium, which intercalates with nucleic acids and emits a red fluorescence detectable qualitatively by fluorescent microscopy or quantitatively by HPLC.

Supplier: Cayman Chemical

5-Fluoro-2'-deoxyuridine (floxuridine)

Supplier: Cayman Chemical

Anti-HMGB1 Mouse Monoclonal Antibody [clone: IMG19N12A1]

Supplier: Cayman Chemical

Doxorubicin is an anthracycline anti-tumour antibiotic which involves in inhibition of DNA topoisomerase II by inducing double-stranded DNA breaks. It is also involved in the inhibition of nucleic acid synthesis by intercalating within DNA. The accumulation of the p53 tumour suppressor protein leads to the apoptosis in cells.

Supplier: Cayman Chemical

Anti-GPR12 Rabbit Polyclonal Antibody

Supplier: Cayman Chemical

Kyselina galová

Supplier: Cayman Chemical

N-Octyl-β-D-glucopyranoside

Supplier: Cayman Chemical

Aprotinin

Supplier: Cayman Chemical

Anti-PORCN Rabbit Polyclonal Antibody

Supplier: Cayman Chemical

Anti-Smt3 Rabbit Polyclonal Antibody

Supplier: Cayman Chemical

Kyselina o-acetylsalicylová

Supplier: Cayman Chemical

5-Fluorouracil

Supplier: Cayman Chemical

Neomycinsulfát

Supplier: Cayman Chemical

Nrf2 Transcription Factor Assay kit is a 96-well assay for measurement of Nrf2.

Supplier: Cayman Chemical

PPM-18 ≥95%

Supplier: Cayman Chemical

Anti-AROS Rabbit Polyclonal Antibody

Supplier: Cayman Chemical

Anti-HDAC4 Rabbit Polyclonal Antibody

Supplier: Cayman Chemical

Anti-SIRT7 Rabbit Polyclonal Antibody

Supplier: Cayman Chemical

Anti-HDAC-6 Rabbit Polyclonal Antibody

Supplier: Cayman Chemical

Anti-Bnc 1 Rabbit Polyclonal Antibody

Supplier: Cayman Chemical

Anti-BLT1 Rabbit Polyclonal Antibody

Supplier: Cayman Chemical

Anti-S1P5 Rabbit Polyclonal Antibody

Supplier: Cayman Chemical

Anti-histone H2A Rabbit Polyclonal Antibody

Supplier: Cayman Chemical

Anti-ANGPTL3 Rat Monoclonal Antibody [clone: Kairos3-3741]

Supplier: Cayman Chemical

Dexmedetomidine is the (S)-enantiomer of medetomidine, an imidazole compound that binds to α2-adrenoceptors (Ki = 1.08 nM) with high affinity and selectivity compared to that of α1-adrenoceptors (Ki = 1.8 μM). Dexmedetomidine produces analgesic, sedative, and anxiolytic effects through both presynaptic activation of α2-adrenoceptors, which inhibits norepinephrine release, and postsynaptic activation of α2-adrenoceptors, which inhibits sympathetic activity and decreases blood pressure and heart rate.

Supplier: Cayman Chemical

Nortriptyline is a tricyclic antidepressant that blocks norepinephrine and serotonin transporters (K_Ds = 4.4 and 18 nM, respectively) more potently than the dopamine transporter (K_D = 1.1 µM). It also antagonises serotonin, histamine, muscarinic, and α-adrenergic receptors (K_is = 5.0, 8.5, 10, 40, and 60 nM for 5-HT_2A, 5-HT_2C, H₁, α₁, and M₁ receptors, respectively).