Bone mass and shape is continuously remodeled by the concerted and balanced action of osteoblasts (bone forming cells) and osteoclasts (bone-resorbing cells). The endocannabinoid system plays an essential role in the maintenance of normal bone mass via signaling through the CB2 receptor.
N-Oleoyl-L-serine is an endogenous lipid that has been reported to stimulate bone formation and to inhibit bone resorption.

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Cumene hydroperoxide

Supplier: Cayman Chemical

Cumene hydroperoxide

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Substance P ELISA kit

Supplier: Cayman Chemical

ELISA kit for the measurement of Substance P.

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α-Hydroxy-o-tolyl-β-D-glucopyranoside

Supplier: Cayman Chemical

Salicin is an alcoholic β-glucoside derived from willow bark that produces anti-inflammatory (including analgesic and antipyretic) effects very similar to that of aspirin. It acts as a non-selective COX inhibitor, exhibiting IC50 values >100 µM for COX-1 and COX-2.

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DAF-FM diacetate ≥98%

Supplier: Cayman Chemical

DAF-FM diacetate is a cell-permeable, fluorescent probe for the detection and bioimaging of nitric oxide (NO) with excitation/emission maxima of 495/515 nm.

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Calcein AM ≥90%

Supplier: Cayman Chemical

Calcein AM is a cell-permeable dye that upon entering live cells is cleaved by intracellular esterases, leaving membrane-impermeant calcein.

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Methylchloroisothiazolinone/methylisothiazolinone mixture 14% (w/v) vodný roztok

Supplier: Cayman Chemical

Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) is a mixture of isothiazolinone-derived biocides.1,2 It is effective against Gram-positive and Gram-negative bacteria with MIC values of 0.0002, 0.0002, 0.00005, and 0.00005% (w/w) for S. aureus, P. aeruginosa, A. niger, and C. albicans, respectively.2 MCIT/MIT can elicit contact sensitization.3 Formulations containing MCIT/MIT have been used for controlling microbial growth in industrial and household products.

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Cystamine dihydrochloride ≥95%, crystalline solid

Supplier: Cayman Chemical

Cystamine is an organic disulfide that inhibits TGM2 with an IC50 value of approximately 2.5 mM.

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BAM 7 ≥98%

Supplier: Cayman Chemical

BAM 7 ≥98%

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Benfotiamine ≥98%

Supplier: Cayman Chemical

Benfotiamine is a lipid-soluble form of vitamin B1 (thiamine). in vitro, it corrects defective replication of, and prevents formation of advanced glycosylation end products (AGEs) in, human umbilical vein endothelial cells (HUVECs) grown under high glucose conditions. in vivo, administration of benfotiamine increases nerve conduction velocity (NCV) and prevents microalbuminuria, proteinuria, and formation of AGEs in mice with streptozotocin-induced diabetes.

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Cysteaminium chloride ≥95%, crystalline solid

Supplier: Cayman Chemical

Cysteamine is a stable aminothiol with radioprotective activities.

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Vitamin D ELISA kit

Supplier: Cayman Chemical

Sensitive ELISA for vitamin D quantification in plasma or serum.

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Sisomicin ≥98%

Supplier: Cayman Chemical

Sisomicin is a broad-spectrum aminoglycoside antibiotic originally isolated from M. inyoensis.

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BI-605906 ≥98%

Supplier: Cayman Chemical

BI-605906 ≥98%

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3-Methylbenzamidoxime

Supplier: Cayman Chemical

3-Methylbenzamidoxime

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3,4-Dihydroxybenzoic acid

Supplier: Cayman Chemical

3,4-Dihydroxybenzoic acid

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Toluen-α-sulfonylfluorid

Supplier: Cayman Chemical

Toluen-α-sulfonylfluorid

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Paroxetine hydrochloride ≥98%

Supplier: Cayman Chemical

Paroxetine is a phenylpiperidine derivative that potently and selectively inhibits the reuptake of serotonin, blocking the human serotonin transporter with a Ki value of 0,72 nM.

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Rivastigmine-L-tartrate ≥95%, crystalline solid

Supplier: Cayman Chemical

Rivastigmine is an irreversible inhibitor of acetylcholinesterase (IC₅₀=4,15 µm) and butyrylcholinesterase (IC₅₀=37 nM).

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Apixaban ≥98%, crystalline solid

Supplier: Cayman Chemical

Apixaban is an orally bioavailable, selective inhibitor of both free and prothrombinase-bound factor Xa (K_is = 0.8 nM).

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Imipenem monohydrate

Supplier: Cayman Chemical

Imipenem is an intravenous β-lactam antibiotic effective against a wide range of Gram-positive and Gram-negative bacteria (MICs range from 0,5 - 2 µg/ml for E. cloacae and P. aeruginosa), including several multi-drug resistant bacterial species. Imipenem acts by interfering with bacterial cell wall synthesis.