Horse Recombinant PDGF-BB (from E. coli)

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About this item

Platelet-derived growth factor (PDGF) is an important regulator of cell growth, proliferation, and angiogenesis. PDGF synthesis is induced by IL-1, IL-6, TNF-α, TGF-β, and EGF signaling. PDGF functions as a mitogenic growth hormone on cells of mesenchymal lineage, such as smooth muscle and glial cells. PDGF is also stored in the alpha-granules of platelets and is released upon adherence to traumatised tissues. PDGF is a dimeric glycoprotein formed by two A chains (AA), two B chains (BB), or as a heterodimer with an A and a B chain (AB). The PDGF dimer binds the cell surface receptor tyrosine kinases PDGFR-α and PDGFR-β.

High quality
Low endotoxin
Affordable

Caution: For research use only.

Specifications

Spojení:
Unconjugated
Proteinový podtyp:
Cytokine
Typ proteinu/peptidu:
Recombinant
Zdroj:
E. coli
Druhy:
Horse
Podmínky uskladnění:
–20 °C
Obsah endotoxinů:
Endotoxin LAL (EU/µg) ≤0,1
Biologická aktivita:
Bioactivity Assay: NR6R 3T3 proliferation, ED₅₀ ≤30 ng/ml, Bioactivity ≥3,3×10⁴ units/mg
Identifikační číslo genu:
XP_005606703
Pokyny pro rekonstituce:
Sterile water at 0,1 mg/ml
Bez obsahu endotoxinů:
N
Bez nosiče:
Y
Bez obsahu proteázy:
N
Bez obsahu živočichů:
N
Proteinová synonyma:
ODGF|GDGF
Název proteinu/peptidu:
PDGF-BB
Čistota:
≥95%
Molekulární hmotnost:
24,8 kDa
Sekvence:
MSLGSLAVAE PAMIAECKTR TEVFEISRRL IDRTNANFLV WPPCVEVQRC SGCCNNRHVQ CRPTQVQLRP VQVRKIEIVR KKPTFKKATV TLEDHLACKC ETVGAARPVT
Úroveň endotoxinů:
Low
Formulace:
10 mM Sodium phosphate, pH 7,5
Bez nukleáz:
N
Třída:
RUO
Transportní teplota:
RT
Testované aplikace:
Bioassay