About this item
IL-7 promotes the stimulation of multipotent (pluripotent) hematopoietic stem cells into lymphoid progenitor cells. IL-7, along with IL-2, 15, and 21, is a member of the common gamma (γc) chain cytokine family.
- High Quality
- Low Endotoxin
- Lot-to-lot Consistency
- Animal Free
- Manufactured following GMP guidelines
Secreted by bone marrow and thymic stromal cells, dendritic cells, intestinal epithelial cells, hepatocytes, and keratinocytes. Signals through its receptor (IL-7R) to promote the differentiation of hematopoietic stem cells into T cells, B cells, and natural killer cells. Is a regulator of intestinal mucosal lymphocyte proliferation. Promotes favorable phenotypes in adoptive cellular therapies such as CAR-T cell therapy when combined with IL-15. The biological activity of CTGrade GMP interleukins and growth factors is standardized, where applicable, to WHO International standards, providing cell and gene therapy developers consistent, lot-to-lot biological activity and performance.
Host cell Protein: ≤30 ng/ml
Host cell DNA: ≤0,01 ng/ml
Sterility testing: No growth
Mycoplasma: Negative
Specifications
- Spojení:Unconjugated
- Proteinový podtyp:Cytokine
- Typ proteinu/peptidu:Recombinant
- Zdroj:E. coli
- Druhy:Human
- Podmínky uskladnění:At or below –20 °C
- Obsah endotoxinů:Endotoxin LAL (EU/µg) ≤0,05
- Biologická aktivita:Bioactivity assay: Proliferation using PHA-activated PBMC, ED50 ≤0,5 ng/ml, Bioactivity ≥1,2x10⁵ IU/µg
- Identifikační číslo genu:P13232
- Pokyny pro rekonstituce:Sterile water at 0.1 - 0.5 mg/ml
- Bez obsahu endotoxinů:N
- Bez nosiče:Y
- Bez obsahu proteázy:N
- Bez obsahu živočichů:Y
- Proteinová synonyma:Lymphopoietin 1 (LP-1)|pre-B cell Factor
- Název proteinu/peptidu:IL-7
- Čistota:≥97%
- Molekulární hmotnost:17,5 kDa
- Sekvence:MDCDIEGKDG KQYESVLMVS IDQLLDSMKE IGSNCLNNEF NFFKRHICDA NKEGMFLFRA ARKLRQFLKM NSTGDFDLHL LKVSEGTTIL LNCTGQVKGR KPAALGEAQP TKSLEENKSL KEQKKLNDLC FLKRLLQEIK TCWNKILMGT KEH
- Úroveň endotoxinů:Low
- Formulace:20 mM sodium phosphate, pH 7,5
- Bez nukleáz:N
- Třída:CTGrade GMP
- Transportní teplota:Ambient
- Testované aplikace:Bioassay