- Bal.:0,05 mg
- Typ enzymu:Recombinant
- Zdroj:Cells
- Druhy:Human
- Sekvence značek:C-6 His tag
- Podmínky uskladnění:Store at −20 °C, stable for 6 months after receipt, please minimise freeze - thaw cycles
- Obsah endotoxinů:<0,1 ng/µg (1 IEU/µg) as determined by LAL test
- Název enzymu:Proprotein Convertase 9
- Synonyma enzymů:Proprotein Convertase Subtilisin/Kexin Type 9, Neural Apoptosis-Regulated Convertase 1, NARC-1, Proprotein Convertase 9, PC9, Subtilisin/Kexin-Like Protease PC9, PCSK9, NARC1
- Čistota:>95% as determined by reducing SDS-PAGE
- Molekulární hmotnost:71,05 kD
- Sekvence:Gln31-Gln692
- Formulace:Supplied as a 0,2 µm filtered solution of 50 mM HEPES, 150 mM NaCl, pH 7,4. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilised protein in ddH₂O. Please aliquot the reconstituted solution to minimise freeze-thaw cycles.
- Testované aplikace:Bioassay
Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily.
This recombinant protein can be used for biological assays. For research use only.
Fusion-Tag: C-6 His tag
PCSK9 is synthesised as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2), and play a role in the neural development.