- Druh protilátky:Primární
- Název antigenu:INTS3
- Klonovalita:Polyclonal
- Spojení:Alexa Fluor® 680
- Hostitel:Rabbit
- Imunochemie:Yes
- ImunoFluorescence:Yes
- Izotyp:IgG
- Reaktivita:Human,Rat,Mouse
- Western blot:Yes
- Epitop:901-1043/1043
- Formulář:Liquid
- Identifikační číslo genu:65123
- Synonyma antigenu:INTS3|INT3|C1orf193|Integrator complex subunit 3|SOSSA|Sensor of ssDNA subunit A|SOSS complex subunit A|Sensor of single-strand DNA complex subunit A|C1orf60|SOSS-A
- Modifikace:Unmodified
- Skladovací pufr:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molekulární hmotnost:118 kDa
- Skladovací teplota:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Koncentrace:1 µg/µl
- Transportní teplota:4 °C
- Imunogen:KLH conjugated synthetic peptide derived from human INTS3
- Čištění:Purified by Protein A
- Typ balení:Vial
- Bal.:100 µl
Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent Signalling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilisation of the complex at DNA damage sites.
Type: Primary
Antigen: INTS3
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 901-1043/1043
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat