- Druh protilátky:Primární
- Název antigenu:ERK1
- Klonovalita:Polyclonal
- Spojení:Alexa Fluor® 750
- Průtoková cytometrie:Yes
- Hostitel:Rabbit
- Imunochemie:Yes
- ImunoFluorescence:Yes
- Izotyp:IgG
- Reaktivita:Chicken,Human,Rat,Mouse
- Western blot:Yes
- Epitop:101-200/380
- Formulář:Liquid
- Identifikační číslo genu:26417
- Synonyma antigenu:MAP kinase 3|Prkm3|p44mapk|MAPK 3|p44-MAPK|Mnk1|Esrk1|MAP kinase isoform p44|Ert2|Mtap2k|p44erk1|Microtubule-associated protein 2 kinase|Erk1|p44|Mapk3|Erk-1|Extracellular signal-regulated kinase 1|Insulin-stimulated MAP2 kinase|p44-ERK1|Mitogen-activated protein kinase 3
- Modifikace:Unmodified
- Skladovací pufr:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molekulární hmotnost:43 kDa
- Skladovací teplota:Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Koncentrace:1 µg/µl
- Transportní teplota:4 °C
- Imunogen:KLH conjugated synthetic peptide derived from human ERK1
- Testované aplikace:ICC
- Čištění:Purified by Protein A
- Typ balení:Vial
- Bal.:100 µl
Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1. Phosphorylates heat shock factor protein 4(HSF4) (By similarity). Highest levels within the nervous system, expressed in different tissues, mostly in intestine, placenta and lung. Increased expression during development. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. Contains 1 protein kinase domain. Binds both upstream activators and downstream substrates in multimolecular complexes. Found in a complex with at least BRAF, HRAS, MAP2K1/MEK1, MAPK3 and RGS14. Interacts with TPRBy similarity. Interacts with ADAM15, ARRB2, CANX, DAPK1 (via death domain), HSF4, IER3, MAP2K1/MEK1, NISCH, and SGK1By similarity. Interacts with MORG1, PEA15 and MKNK2. MKNK2 isoform 1 binding prevents from dephosphorylation and inactivation.
Type: Primary
Antigen: ERK1
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 101-200/380
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat, Chicken