Specifications
- Druh protilátky:Primární
- Název antigenu:Presenilin-1
- Symbol antigenu:PSEN1
- Klonovalita:Polyclonal
- Spojení:Alexa Fluor® 750
- Hostitel:Mouse
- Imunochemie:Yes
- ImunoFluorescence:Yes
- Izotyp:IgG
- Reaktivita:Mouse
- Epitop:10-80/467
- Formulář:Liquid
- Identifikační číslo genu:29192
- Synonyma antigenu:Psnl1|Psen1|Presenilin-1|Protein S182|PS-1
- Modifikace:Unmodified
- Skladovací pufr:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molekulární hmotnost:34/52 kDa
- Skladovací teplota:Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Koncentrace:1 µg/µl
- Transportní teplota:4 °C
- Imunogen:KLH conjugated synthetic peptide derived from rat presenilin 1
- Testované aplikace:ICC
- Čištění:Purified by Protein A
- Typ balení:Vial
- Bal.:100 µl
Specifications
About this item
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyses the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis (By similarity).
Type: Primary
Antigen: Presenilin-1
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 750
Public Immunogen Range: 10-80/467
Host: Mouse
Isotype: IgG
Reactivity: Mouse