- Druh protilátky:Primární
- Název antigenu:ERK5 Ser731+Thr733
- Klonovalita:Polyclonal
- Spojení:Alexa Fluor® 680
- Hostitel:Rabbit
- Imunochemie:Yes
- ImunoFluorescence:Yes
- Izotyp:IgG
- Reaktivita:Human
- Western blot:Yes
- Formulář:Liquid
- Identifikační číslo genu:5598
- Synonyma antigenu:ERK4|ERK-5|Extracellular signal-regulated kinase 5|MAP kinase 7|MAPK7|BMK-1|MAPK 7|ERK5|PRKM7|BMK1|Mitogen-activated protein kinase 7|Big MAP kinase 1
- Modifikace:Phosphorylation ( Ser731+Thr733)
- Skladovací pufr:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molekulární hmotnost:90 kDa
- Skladovací teplota:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Koncentrace:1 µg/µl
- Transportní teplota:4 °C
- Imunogen:KLH conjugated synthetic phosphopeptide derived from human ERK5 around the phosphorylation sites of Ser731+Thr733
- Testované aplikace:ICC
- Čištění:Purified by Protein A
- Typ balení:Vial
- Bal.:100 µl
Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.
Type: Primary
Antigen: ERK5 Ser731+Thr733
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range:
Host: Rabbit
Isotype: IgG
Reactivity: Human