Specifications
- Druh protilátky:Primární
- Název antigenu:Nucleophosmin
- Klonovalita:Polyclonal
- Spojení:Alexa Fluor® 680
- Hostitel:Rabbit
- Imunochemie:Yes
- ImunoFluorescence:Yes
- Izotyp:IgG
- Reaktivita:Human,Rat,Mouse
- Western blot:Yes
- Epitop:21-120/259
- Formulář:Liquid
- Identifikační číslo genu:4869
- Synonyma antigenu:NPM|Numatrin|Nucleophosmin|Nucleolar protein NO38|B23|Nucleolar phosphoprotein B23|NPM1
- Modifikace:Unmodified
- Skladovací pufr:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molekulární hmotnost:33 kDa
- Skladovací teplota:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Koncentrace:1 µg/µl
- Transportní teplota:4 °C
- Imunogen:KLH conjugated synthetic peptide derived from human Nucleophosmin
- Testované aplikace:ICC
- Čištění:Purified by Protein A
- Typ balení:Vial
- Bal.:100 µl
Specifications
About this item
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidised rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation.
Type: Primary
Antigen: Nucleophosmin
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 21-120/259
Host: Rabbit
Isotype: IgG
Reactivity: Human; Mouse; Rat