Human recombinant FGF-21 (from E. coli)

O tomto produktu

Fibroblast growth factor 21 (FGF21) is an endocrine hormone that regulates energy homeostasis and exerts cardioprotective functions during heart injury. FGF21 is expressed in the liver, pancreas, heart, and adipose tissues.

Produced from genetically modified E. coli
Monomeric protein, containing 182 amino acids

FGF21 signaling is activated through the FGFR1c receptor and ß-Klotho co-receptor. FGF21 is an important regulator of glucose uptake and reduces cell apoptosis under stress conditions.

Delivery: Certificate of Analysis (COA) is supplied with each product shipped detailing purity, formulation, biological activity, endotoxin levels, reconstitution instructions and recommended storage conditions.

Caution: This product is for research use only and is not for use in humans.

Specifikace

Spojení:
Unconjugated
Proteinový podtyp:
Cytokine
Typ proteinu/peptidu:
Recombinant
Zdroj:
E. coli
Druhy:
Human
Podmínky uskladnění:
–20 °C
Obsah endotoxinů:
Endotoxin LAL (EU/µg) ≤0,1
Biologická aktivita:
Bioactivity assay: NIH-3T3 proliferation with β-klotho and heparin, ED50 ≤500 ng/ml, Bioactivity ≥2,0 ×10³ unit/mg
Identifikační číslo genu:
Q9NSA1
Pokyny pro rekonstituce:
Sterile water at 0.1 mg/ml
Bez obsahu endotoxinů:
N
Bez nosiče:
Y
Bez obsahu proteázy:
N
Bez obsahu živočichů:
N
Proteinová synonyma:
FGFL
Název proteinu/peptidu:
FGF-21
Čistota:
≥95%
Molekulární hmotnost:
19,5 kDa
Sekvence:
MHPIPDSSPL LQFGGQVRQR YLYTDDAQQT EAHLEIREDG TVGGAADQSP ESLLQLKALK PGVIQILGVK TSRFLCQRPD GALYGSLHFD PEACSFRELL LEDGYNVYQS EAHGLPLHLP GNKSPHRDPA PRGPARFLPL PGLPPALPEP PGILAPQPPD VGSSDPLSMV GPSQGRSPSY AS
Úroveň endotoxinů:
Low
Formulace:
10 mM sodium phosphate, 100 mM sodium chloride, pH 7,5
Bez nukleáz:
N
Třída:
RUO
Transportní teplota:
RT
Testované aplikace:
Bioassay