Rat Recombinant TNFalpha (from E. coli)

About this item

Tumor necrosis factor alpha (TNF-α) is an inflammatory cytokine secreted by macrophages, monocytes, neutrophils, T cells, and NK-cells following stimulation by bacterial lipopolysaccharide (LPS). TNF-α signal activation occurs through two receptors, TNFR1 and TNFR2. TNFR1 is expressed on most cell types, unlike TNFR2, which is expressed mainly on immune cells. TNF-α functions to stimulate phagocytosis in macrophages, chemoattract neutrophils, increase insulin resistance, and induce fever.

High Quality
Low Endotoxin
Affordable

A COA is supplied with each product shipped detailing purity, formulation, biological activity, endotoxin levels, reconstitution instructions and recommended storage conditions. This product is for research use only and is not for use in humans.

Caution: For research use only.

Specifications

Spojení:
Unconjugated
Proteinový podtyp:
Cytokine
Typ proteinu/peptidu:
Recombinant
Zdroj:
E. coli
Druhy:
Rat
Podmínky uskladnění:
–20 °C
Obsah endotoxinů:
Endotoxin LAL (EU/µg) ≤1
Biologická aktivita:
Bioactivity assay: Cytolysis of mouse L929 cells in the presence of Actinomycin D, ED50 ≤0,05 ng/ml, Bioactivity ≥2,0×10⁷ units/mg
Identifikační číslo genu:
P16599
Pokyny pro rekonstituce:
Sterile water at 0.1 mg/ml
Bez obsahu endotoxinů:
N
Bez nosiče:
Y
Bez obsahu proteázy:
N
Bez obsahu živočichů:
N
Proteinová synonyma:
Cytotoxin|DIF|Necrosin|Cachexin|TNFSF2|TNF|Cachectin
Název proteinu/peptidu:
TNFalpha
Čistota:
≥95%
Molekulární hmotnost:
17,3 kDa
Sekvence:
MLRSSSQNSS DKPVAHVVAN HQAEEQLEWL SQRANALLAN GMDLKDNQLV VPADGLYLIY SQVLFKGQGC PDYVLLTHTV SRFATSYQEK VSLLSAIKSP CPKDTPEGAE LKPWYEPMYL GGVSQLEKGD LLSAEVNLPK YLDITESGQV YFGVIAL
Úroveň endotoxinů:
Low
Formulace:
10 mM sodium phosphate, 50 mM sodium chloride, pH 7,5
Bez nukleáz:
N
Třída:
RUO
Transportní teplota:
RT
Testované aplikace:
Bioassay