This kit has been designed for monitoring protein stability under systematic thermal stress conditions.

• Accelerated screening for protein stability as a function of pH, ionic strength, and concentration
• Can detect ligand binding, even without a prior knowledge of the protein’s function or ligand binding site
• Provides a convenient, complementary orthogonal method for cross-validation of instrumentation-intensive techniques

The aggregation temperature is an indicator of protein stability and can be used to optimize conditions that minimize protein aggregation as well as to identify ligands that bind and confer structural stability to a protein of interest. Conditions that increase the aggregation temperature, increase the stability of the protein.