Specifications
- Bal.:50 µG
- Typ enzymu:Recombinant
- Zdroj:E. coli
- Druhy:Human
- Sekvence značek:C-6 His tag
- Podmínky uskladnění:Store at −20 °C, stable for 6 months after receipt. Please minimize freeze−thaw cycles.
- Název enzymu:B Lymphocyte Kinase
- Čistota:>95% as determined by reducing SDS-PAGE
- Molekulární hmotnost:58.7 kD
- Sekvence:Gly2-Pro505
- Formulace:Supplied as a 0.2 µm filtered solution of 20 mM Tris, 500 mM NaCl, 1 mM DTT, pH 7.4. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH₂O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
- Testované aplikace:Bioassay
Specifications
About this item
Tyrosine-Protein Kinase Blk (BLK) contains one protein kinase domain, one SH2 domain and one SH3 domain. BLK is a non-receptor tyrosine kinase, which is involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulines and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Defects in BLK are a cause of maturity-onset diabetes of the young type 11 (MODY11).
Fusion-Tag: C-6 His tag
This recombinant protein can be used for biological assays. For research use only.