Specifications
- Druh protilátky:Primární
- Název antigenu:Solute Carrier Family 25 Member A12
- Symbol antigenu:SLC25A12
- Klonovalita:Polyclonal
- Spojení:FITC (Fluorescein Isothiocyanate)
- Hostitel:Rabbit
- Imunochemie:Yes
- Izotyp:IgG
- Reaktivita:Human,Rat,Mouse
- Křížová adsorbce:No
- Formulář:liquid
- Synonyma antigenu:solute carrier family 25|ARALAR1|CMC1_HUMAN|Araceli hiperlarga|Mitochondrial aspartate glutamate carrier 1|Calcium-binding mitochondrial carrier protein Aralar1|Solute carrier family 25 member 12|member 12.|ARALAR|Calcium binding mitochondrial carrier superfamily member|AGC1|SLC25A12
- Skladovací pufr:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Skladovací teplota:Store at 4°C for 12 months
- Koncentrace:1 μg/μl
- Transportní teplota:4°C
- Čištění:Purified by Protein A
- Bal.:100 µl
Specifications
About this item
Calcium signaling in mitochondria is important in order for it to function in response to a variety of extracellular stimuli. Signaling begins with Ca(2+) entry in mitochondria via the Ca(2+) uniporter followed by Ca(2+) activation of three dehydrogenases in the mitochondrial matrix. ARALAR, the neuronal Ca(2+)-binding mitochondrial aspartate-glutamate carrier, has Ca(2+) binding domains facing the extramitochondrial space and functions in the malate-aspartate NADH shuttle (MAS). ARALAR is encoded by the SLC25A12 gene and is expressed in brain and skeletal muscle. ARALAR is required for the synthesis of brain aspartate and N-acetylaspartatemay and plays a role in myelin formation. It is also essential for the transmission of small Ca(2+) signals to mitochondria via an increase in mitochondrial NADH. In addition, ARALAR is implicated in conferring susceptibility to schizophrenia.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: SLC25A12
Clonality: Polyclonal
Clone:
Conjugation: FITC (Fluorescein Isothiocyanate)
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat